Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCN4 | Q9Y3Q4 | 6/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | SMPD1 | P17405 | 3/20 | 0.38 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11091288 | 0.85 | HCN4 (0.55) | HCN4BRD4MAPTCYP3A4ALOX15 | |
| Hydrochloric Acid SCHEMBL10984135 | 0.81 | CYP3A4 (0.64) | HCN4MAPTCYP3A4ALOX15SMPD1 | |
| SCHEMBL10667192 | 0.79 | HCN4 (0.48) | HCN4BRD4MAPTCYP3A4ALOX15 | |
| SCHEMBL10894643 | 0.79 | HCN4 (0.48) | HCN4BRD4MAPTCYP3A4SMPD1 | |
| SCHEMBL10669932 | 0.79 | HCN4 (0.50) | HCN4BRD4MAPTCYP3A4ALOX15 | |
| SCHEMBL10985132 | 0.79 | HCN4 (0.73) | HCN4BRD4MAPTCYP3A4ALOX15 | |
| Hydrochloric Acid SCHEMBL10667216 | 0.78 | HCN4 (0.49) | HCN4BRD4MAPTCYP3A4ALOX15 | |
| SCHEMBL10671624 | 0.78 | HCN4 (0.50) | HCN4BRD4MAPTCYP3A4ALOX15 | |
| SCHEMBL11092035 | 0.78 | HCN4 (0.61) | HCN4BRD4MAPTCYP3A4ALOX15 | |
| Hydrochloric Acid SCHEMBL10986664 | 0.78 | HCN4 (0.72) | HCN4BRD4MAPTCYP3A4ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4490369-A | HYPOTENSIVE, BRRADYCARDIAL | DR. KARL THOMAE GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1984-12-25 | — | — | US | disclosed |
| EP-0065229-A1 | Benzazepines, process for their preparation and their application as pharmaceutical preparations | Dr. Karl Thomae GmbH (DE) | 1982-11-24 | — | — | EP | disclosed |