Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PLD2 | O14939 | 1/20 | 0.41 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.41 |
| ▸ | SCN1A | P35498 | 1/20 | 0.40 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.39 |
| ▸ | TUBB | P07437 | 1/20 | 0.39 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11100292 | 0.91 | ALDH1A1 (0.46) | ALDH1A1GAAHTTPOLBMAPT | |
| SCHEMBL11096821 | 0.83 | SCN1A (0.47) | POLBMAPTSCN1ASCN5ASCN9A | |
| SCHEMBL11097138 | 0.79 | MAOB (0.54) | ALDH1A1HTTTAAR1MAPTMEN1 | |
| SCHEMBL11493471 | 0.76 | SIGMAR1 (0.48) | POLBSIGMAR1LMNA | |
| SCHEMBL11101000 | 0.75 | ALDH1A1 (0.41) | ALDH1A1GAAMAPTSCN1ASCN5A | |
| SCHEMBL11099575 | 0.73 | CHRM4 (0.48) | ALDH1A1POLBMAPTSCN1ASCN5A | |
| SCHEMBL11180233 | 0.72 | ALDH1A1 (0.45) | ALDH1A1GAAHTTPOLBMAPT | |
| SCHEMBL11031363 | 0.72 | PLD2 (0.73) | ALDH1A1PLD2PLD1KDM4ELMNA | |
| SCHEMBL11096272 | 0.71 | CHRM2 (0.54) | SIGMAR1 | |
| SCHEMBL11099931 | 0.70 | ALDH1A1 (0.38) | ALDH1A1GAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0029707-B1 | NOVEL PIPERIDINE DERIVATIVES, METHOD FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | KYOWA HAKKO KOGYO CO., LTD (JP) | 1984-02-01 | — | — | EP | disclosed |
| US-4390536-A | HYPOTENSIVE AGENTS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1983-06-28 | — | — | US | disclosed |
| US-4344945-A | HYPOTENSIVE AGENTS, BENZOXAZINYL DERIVATIVES | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1982-08-17 | — | — | US | disclosed |
| EP-0029707-A1 | Novel piperidine derivatives, method for the preparation thereof and pharmaceutical compositions containing them | KYOWA HAKKO KOGYO CO., LTD (JP) | 1981-06-03 | — | — | EP | disclosed |