Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTNNB1 | P35222 | 5/20 | 0.47 |
| ▸ | TCF7L2 | Q9NQB0 | 5/20 | 0.47 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 6/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.39 |
| ▸ | TP53 | P04637 | 4/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.39 |
| ▸ | USP2 | O75604 | 2/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | MERTK | Q12866 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11095223 | 0.82 | LMNA (0.43) | ADORA3TSHRALDH1A1KDM4EHSD17B10 | |
| SCHEMBL11100924 | 0.80 | ADORA3 (0.38) | ADORA3ALDH1A1KDM4ELMNACYP2C19 | |
| SCHEMBL10970832 | 0.74 | ADORA3 (0.55) | ADORA3TSHRALDH1A1KDM4ECLK4 | |
| SCHEMBL10970416 | 0.71 | MAPT (0.39) | TSHRALDH1A1KDM4EHSD17B10LMNA | |
| SCHEMBL11098958 | 0.69 | KMT2A (0.38) | ALDH1A1KDM4EHSD17B10USP2LMNA | |
| SCHEMBL25247772 | 0.68 | NUDT1 (0.61) | CTNNB1TCF7L2NUDT1TSHRALDH1A1 | |
| SCHEMBL10971806 | 0.68 | MAPT (0.55) | KDM4ECYP1A2CYP3A4LMNACYP2C19 | |
| SCHEMBL10970373 | 0.67 | MAPT (0.54) | KDM4ECYP1A2CYP3A4LMNACYP2C19 | |
| SCHEMBL1620437 | 0.66 | NUDT1 (0.62) | NUDT1TSHRALDH1A1KDM4EHSD17B10 | |
| SCHEMBL10970489 | 0.65 | MAPT (0.52) | KDM4ETP53CYP1A2CYP3A4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0030156-B1 | QUINAZOLINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1984-03-21 | — | — | EP | disclosed |
| US-4429126-A | ANTIASTHMA | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1984-01-31 | — | — | US | disclosed |
| US-4377580-A | ANTIALLERGENIC AGENTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1983-03-22 | — | — | US | disclosed |
| EP-0030156-A1 | Quinazoline derivatives, processes for their preparation and pharmaceutical compositions containing them | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1981-06-10 | — | — | EP | disclosed |