Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | CES2 | O00748 | 3/20 | 0.42 |
| ▸ | CES1 | P23141 | 3/20 | 0.42 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11204713 | 0.83 | ALDH1A1 (0.47) | ALDH1A1CYP1A2TSHRCES2CES1 | |
| SCHEMBL6417147 | 0.83 | TRPA1 (0.47) | ALDH1A1CYP1A2ALOX15TSHRCES2 | |
| SCHEMBL634548 | 0.79 | CES2 (0.50) | ALDH1A1CYP1A2ALOX15TSHRCES2 | |
| SCHEMBL28117241 | 0.78 | ALOX15 (0.48) | ALDH1A1ALOX15TSHRPOLBCES2 | |
| SCHEMBL8683450 | 0.77 | ALOX15 (0.52) | ALDH1A1ALOX15TSHRPOLBCES2 | |
| SCHEMBL28750316 | 0.75 | ALDH1A1 (0.47) | ALDH1A1CYP1A2TSHRTRPA1KMT2A | |
| SCHEMBL10832344 | 0.75 | HDAC3 (0.49) | ALDH1A1ALOX15TSHRPOLBCES2 | |
| SCHEMBL2625462 | 0.74 | CES2 (0.54) | ALDH1A1ALOX15TSHRCES2CES1 | |
| SCHEMBL20995299 | 0.74 | CES2 (0.54) | ALDH1A1ALOX15TSHRCES2CES1 | |
| SCHEMBL3424507 | 0.74 | GSK3B (0.61) | ALDH1A1ALOX15TSHRCES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0037710-B1 | THIAZOLE DERIVATIVES | JOHN WYETH & BROTHER LIMITED (GB) | 1984-08-01 | — | — | EP | disclosed |
| US-4385059-A | 4-(4-CHLOROPHENYL)-2-(4-HYDROXYPHENYL)THIAZOLE-5-ACETIC ACID | JOHN WYETH AND BROTHER LIMITED (GB) | 1983-05-24 | — | — | US | disclosed |
| EP-0037710-A1 | Thiazole derivatives | JOHN WYETH & BROTHER LIMITED (GB) | 1981-10-14 | — | — | EP | disclosed |