Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 3/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.71 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.71 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.71 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.71 |
| ▸ | TSHR | P16473 | 1/20 | 0.71 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.71 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.71 |
| ▸ | LMNA | P02545 | 3/20 | 0.69 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.53 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.53 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.53 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.53 |
| ▸ | GMNN | O75496 | 1/20 | 0.52 |
| ▸ | APEX1 | P27695 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11181937 | 0.92 | ALDH1A1 (0.59) | CYP2D6ALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL11296600 | 0.91 | ALDH1A1 (0.58) | CYP2D6ALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL11403393 | 0.89 | CYP1A2 (0.56) | CYP2D6ALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL10515489 | 0.88 | ALDH1A1 (0.55) | CYP2D6ALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL11205002 | 0.84 | ALDH1A1 (0.51) | CYP2D6ALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL11188095 | 0.84 | CYP2D6 (0.74) | CYP2D6ALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL11180591 | 0.83 | ALDH1A1 (0.49) | CYP2D6ALDH1A1CYP1A2CYP3A4CYP2C9 | |
| Telenzepine SCHEMBL49345 | 0.83 | CYP2D6 (1.00) | CYP2D6ALDH1A1CYP1A2CYP3A4CYP2C9 | |
| Telenzepine SCHEMBL184401 | 0.82 | LMNA (1.00) | CYP2D6ALDH1A1CYP1A2CYP3A4CYP2C9 | |
| Telenzepine SCHEMBL2006403 | 0.82 | CYP2D6 (0.98) | CYP2D6ALDH1A1CYP1A2CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0039519-B1 | SUBSTITUTED THIENOTRICYCLES, PROCESS FOR THEIR PREPARATION AND THERAPEUTICAL AGENTS CONTAINING THEM | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 1984-05-02 | — | — | EP | disclosed |
| US-4381301-A | Substituted tricyclic thieno compounds, their synthesis, their use, their compositions and their medicaments | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1983-04-26 | — | — | US | disclosed |
| WO-1981003173-A1 | THIENO-TRICYCLIC COMPOUNDS,METHOD FOR THE PREPARATION THEREOF,UTILIZATION OF SUCH COMPOUNDS AND DRUGS CONTAINING THEM | BYK GULDEN LOMBERG CHEM FAB (DE) | 1981-11-12 | — | — | WO | disclosed |
| EP-0039519-A1 | Substituted thienotricycles, process for their preparation and therapeutical agents containing them | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 1981-11-11 | — | — | EP | disclosed |