Telenzepine

Telenzepine

SCHEMBL184401

Cc1scc2c1N(C(=O)CN1CCN(C)CC1)c1ccccc1NC2=O.Cl.Cl

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Telenzepine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CHRM1 known ✓ P11229 4/20 0.56
CHRM2 known ✓ P08172 3/20 0.56
CHRM4 known ✓ P08173 2/20 0.56
CHRM3 known ✓ P20309 2/20 0.56
CHRM5 known ✓ P08912 1/20 0.56
LMNA P02545 3/20 1.00
CYP2D6 P10635 3/20 0.98
ALDH1A1 P00352 2/20 0.98
CYP1A2 P05177 2/20 0.98
CYP3A4 P08684 2/20 0.98
CYP2C9 P11712 1/20 0.98
TSHR P16473 1/20 0.98
CYP2C19 P33261 1/20 0.98
L3MBTL1 Q9Y468 1/20 0.98
GMNN O75496 1/20 0.58
APEX1 P27695 1/20 0.58
USP2 O75604 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Telenzepine SCHEMBL970991 1.00 LMNA (1.00) LMNACYP2D6ALDH1A1CYP1A2CYP3A4
Telenzepine SCHEMBL49345 0.99 CYP2D6 (1.00) LMNACYP2D6ALDH1A1CYP1A2CYP3A4
Telenzepine SCHEMBL2006403 0.98 CYP2D6 (0.98) LMNACYP2D6ALDH1A1CYP1A2CYP3A4
Telenzepine SCHEMBL14973496 0.97 ALDH1A1 (0.96) LMNACYP2D6ALDH1A1CYP1A2CYP3A4
SCHEMBL11192698 0.91 ALDH1A1 (0.85) LMNACYP2D6ALDH1A1CYP1A2CYP3A4
SCHEMBL9431778 0.89 ALDH1A1 (0.82) LMNACYP2D6ALDH1A1CYP1A2CYP3A4
SCHEMBL9727995 0.89 ALDH1A1 (0.81) LMNACYP2D6ALDH1A1CYP1A2CYP3A4
SCHEMBL11187135 0.88 CYP2D6 (0.80) LMNACYP2D6ALDH1A1CYP1A2CYP3A4
Pirenzepine SCHEMBL935909 0.88 ALDH1A1 (0.79) LMNACYP2D6ALDH1A1CYP1A2CYP3A4
SCHEMBL9431091 0.87 ALDH1A1 (0.78) LMNACYP2D6ALDH1A1CYP1A2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 220 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260000646-A1 Inhibition of Oral Microbe Biofilms THE UNIVERSITY OF TOLEDO (US) 2026-01-01 US claimed
WO-2023229993-A1 OPHTHALMIC FORMULATION CAPABLE OF DELIVERING METFORMIN TO CHOROID RPE AND RETINA CURATIVE BIOTECHNOLOGY, INC. (US) 2023-11-30 WO claimed
EP-4027985-A1 DRUGGABLE TARGET TO TREAT RETINAL DEGENERATION The United States of America, as represented by The Secretary, Department of Health and Human Services (US) 2022-07-20 EP claimed
CN-114650813-A Druggable targets for the treatment of retinal degeneration 美国卫生和人力服务部 2022-06-21 CN claimed
WO-2021050980-A1 DRUGGABLE TARGET TO TREAT RETINAL DEGENERATION THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH & HUMAN SERVICES (US) 2021-03-18 WO claimed
US-20050107349-A1 Method for the treatment or prevention of respiratory disorders with a cyclooxygenase-2 inhibitor in combination with a muscarinic receptor antagonist and compositions therewith PHARMACIA CORPORATION (US) 2005-05-19 US claimed
EP-1328261-A2 TREATMENT OF NEURODEGENERATIVE DISEASE Minerva Biotechnologies Corporation (US) 2003-07-23 EP claimed
US-20030060487-A1 Treatment of neurodegenerative disease MINERVA BIOTECHNOLOGIES CORPORATION 2003-03-27 US claimed
WO-2001078709-A2 TREATMENT OF NEURODEGENERATIVE DISEASE MINERVA BIOTECHNOLOGIES CORPORATION (US) 2001-10-25 WO claimed
EP-4680243-A1 METHODS FOR TREATMENT OF AGE-RELATED MACULAR DEGENERATION The United States of America, as represented by the Secretary, Department of Health and Human Services (US) 2026-01-21 EP disclosed
US-20260000646-A1 Inhibition of Oral Microbe Biofilms THE UNIVERSITY OF TOLEDO (US) 2026-01-01 US disclosed
WO-2024196814-A1 METHODS FOR TREATMENT OF AGE-RELATED MACULAR DEGENERATION THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2024-09-26 WO disclosed
WO-2023229993-A1 OPHTHALMIC FORMULATION CAPABLE OF DELIVERING METFORMIN TO CHOROID RPE AND RETINA CURATIVE BIOTECHNOLOGY, INC. (US) 2023-11-30 WO disclosed
US-20220339127-A1 DRUGGABLE TARGET TO TREAT RETINAL DEGENERATION THE UNITED STATES OF AMERICA,AS REPRESENTED BY THE SECRETARY,DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2022-10-27 US disclosed
US-5700795-A ADMINISTERING AT PREDETERMINED TIME TO DECREASE HYPERINSULINEMIA, HYPERGLYCEMIA, INSULIN RESISTANCE THE GENERAL HOSPITAL CORPORATION (US) 1997-12-23 US disclosed
US-5668155-A ALTERING LIPID METABOLISM IN VERTEBRATES FOR REDUCTION OF FATS THE GENERAL HOSPITAL CORPORATION (US) 1997-09-16 US disclosed
EP-0764026-A1 ADMINISTRATION OF PIRENZEPINE, METHYL SCOPOLAMINE AND OTHER MUSCARINIC RECEPTOR ANTAGONISTS FOR TREATMENT OF LIPID METABOLISM DISORDERS ERGO SCIENCE INCORPORATED (US) 1997-03-26 EP disclosed
WO-1995035110-A1 ADMINISTRATION OF PIRENZEPINE, METHYL SCOPOLAMINE AND OTHER MUSCARINIC RECEPTOR ANTAGONISTS FOR TREATMENT OF LIPID METABOLISM DISORDERS ERGO SCIENCE INCORPORATED (US) 1995-12-28 WO disclosed
US-5324832-A Muscarinic antagonists THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 1994-06-28 US disclosed
WO-1993000906-A1 MUSCARINIC ANTAGONISTS THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 1993-01-21 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030060487-A1 Treatment of neurodegenerative disease HTT, IAPP, APP CHRM1 3695/4885CHRM2 3018/4885CHRM4 2728/4885
US-20260000646-A1 Inhibition of Oral Microbe Biofilms NOX5, NOX1, NOX3 CHRM1 1566/4885CHRM2 1130/4885CHRM4 2019/4885
US-20050107349-A1 Method for the treatment or prevention of respiratory disorders with a cyclooxygenase-2 inhibitor in combination with a muscarinic receptor antagonist and compositions therewith CHRM3, CYSLTR2, CHRM2 CHRM1 18/4885CHRM2 3/4885CHRM4 23/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.