Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.44 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.44 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.44 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.44 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.44 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.44 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 4/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | GRM5 | P41594 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.41 |
| ▸ | PRKCA | P17252 | 1/20 | 0.41 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11070583 | 0.85 | KDM4E (0.52) | KDM4EALDH1A1HPGDPSEN1PSEN2 | |
| SCHEMBL11094768 | 0.83 | KDM4E (0.50) | KDM4EALDH1A1HPGDPSEN1PSEN2 | |
| SCHEMBL11098906 | 0.83 | MAOB (0.49) | KDM4EFFAR4ALDH1A1PTGER1MAOB | |
| SCHEMBL11094584 | 0.82 | PPARG (0.57) | KDM4EALDH1A1HPGDMAOBPOLB | |
| SCHEMBL3498584 | 0.80 | KDM4E (0.49) | KDM4EALDH1A1HPGDPTGER1POLB | |
| SCHEMBL11098397 | 0.79 | PPARG (0.52) | KDM4EALDH1A1HPGDMAOBPOLB | |
| SCHEMBL11096460 | 0.79 | DRD4 (0.43) | FFAR4ALDH1A1MAOBMAOANR4A2 | |
| SCHEMBL8564199 | 0.78 | MAPT (0.51) | KDM4EALDH1A1HPGDPOLBGAA | |
| SCHEMBL11098840 | 0.78 | DRD4 (0.44) | ALDH1A1MAOBMAOANR4A2L3MBTL1 | |
| SCHEMBL11119450 | 0.77 | KDM4E (0.48) | KDM4EALDH1A1HPGDPSEN1PSEN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0033094-B1 | IMIDAZO(1,2-A)PYRIDINES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SCHERING CORPORATION (US) | 1984-10-10 | — | — | EP | disclosed |
| EP-0033094-A1 | Imidazo(1,2-a)pyridines, processes for their preparation and pharmaceutical compositions containing them | SCHERING CORPORATION (US) | 1981-08-05 | — | — | EP | disclosed |