Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | ADH5 | P11766 | 8/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.32 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.32 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.32 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.31 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.31 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.31 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.31 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.31 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11104830 | 0.78 | PDE3B (0.36) | PDE3BPDE3AADH5CYP3A4CYP11B1 | |
| SCHEMBL11101040 | 0.77 | PDE3B (0.57) | PDE3BPDE3AADH5CYP3A4LMNA | |
| SCHEMBL10649130 | 0.75 | PDE3B (0.65) | PDE3BPDE3AADH5IDO1 | |
| SCHEMBL14307267 | 0.71 | CYP3A4 (0.46) | PDE3BPDE3ACYP3A4CYP11B1CYP11B2 | |
| SCHEMBL10649836 | 0.68 | PDE3B (0.35) | PDE3BPDE3AADH5PSEN1PSEN2 | |
| SCHEMBL10365557 | 0.68 | PDE3B (0.47) | PDE3BPDE3AADH5IDO1 | |
| SCHEMBL10648603 | 0.68 | PDE3B (0.46) | PDE3BPDE3AADH5IDO1 | |
| SCHEMBL10364553 | 0.68 | PDE3B (0.44) | PDE3BPDE3AADH5CYP3A4IDO1 | |
| SCHEMBL14282012 | 0.67 | CYP11B1 (0.42) | CYP3A4CYP11B1CYP11B2IDO1CYP19A1 | |
| SCHEMBL11099462 | 0.67 | PDE3B (0.39) | PDE3BPDE3ACYP3A4CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0122419-A2 | Substituted 3-mercaptopyridazines, their 3-alkylthio derivatives and processes for their preparation | A. Nattermann & Cie. GmbH (DE) | 1984-10-24 | — | — | EP | disclosed |