Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTBP2 | P56545 | 3/20 | 0.59 |
| ▸ | CA2 | P00918 | 9/20 | 0.57 |
| ▸ | CA1 | P00915 | 7/20 | 0.57 |
| ▸ | CA9 | Q16790 | 6/20 | 0.53 |
| ▸ | CA12 | O43570 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | CES2 | O00748 | 1/20 | 0.45 |
| ▸ | CES1 | P23141 | 1/20 | 0.45 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.45 |
| ▸ | FNTA | P49354 | 1/20 | 0.43 |
| ▸ | FNTB | P49356 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11110696 | 1.00 | CTBP2 (0.59) | CTBP2CA2CA1CA9CA12 | |
| SCHEMBL20446972 | 0.84 | CA2 (0.46) | CTBP2CA2CA1CA9CA12 | |
| SCHEMBL953785 | 0.84 | CA2 (0.46) | CTBP2CA2CA1CA9CA12 | |
| SCHEMBL19053351 | 0.84 | CA2 (0.46) | CTBP2CA2CA1CA9CA12 | |
| SCHEMBL953786 | 0.84 | CA2 (0.46) | CTBP2CA2CA1CA9CA12 | |
| SCHEMBL23780246 | 0.84 | CA2 (0.46) | CTBP2CA2CA1CA9CA12 | |
| SCHEMBL9026937 | 0.80 | CA2 (0.43) | CTBP2CA2CA1CA9CA12 | |
| SCHEMBL29346014 | 0.80 | CTBP2 (0.61) | CTBP2ALDH1A1L3MBTL1CES2CES1 | |
| SCHEMBL11888718 | 0.80 | CTBP2 (0.61) | CTBP2ALDH1A1L3MBTL1CES2CES1 | |
| SCHEMBL5597204 | 0.79 | ALDH1A1 (0.47) | CTBP2CA2CA1CA9ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0048911-B1 | O-SUBSTITUTED OXIMES OF ALPHA-KETOCARBOXYLIC ACID, PREPARATION AND PHARMACEUTICAL COMPOSITIONS | Roche Diagnostics GmbH (DE) | 1984-12-05 | — | — | EP | disclosed |
| US-4425360-A | Pharmacologically active novel O-substituted pyruvic acid oximes | BOEHRINGER MANNHEIM GMBH (DE) | 1984-01-10 | — | — | US | disclosed |
| EP-0048911-A2 | O-substituted oximes of alpha-ketocarboxylic acid, preparation and pharmaceutical compositions | Roche Diagnostics GmbH (DE) | 1982-04-07 | — | — | EP | disclosed |