Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 2/20 | 0.47 |
| ▸ | IMPDH2 | P12268 | 2/20 | 0.44 |
| ▸ | CNR1 | P21554 | 2/20 | 0.43 |
| ▸ | CNR2 | P34972 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | METAP1 | P53582 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.38 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ATR | Q13535 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2085297 | 0.84 | RAB9A (0.41) | ADORA2ASMN1; SMN2L3MBTL1RAB9AMEN1 | |
| SCHEMBL20263079 | 0.84 | RAB9A (0.41) | ADORA2ASMN1; SMN2L3MBTL1RAB9AMEN1 | |
| SCHEMBL28031146 | 0.82 | TSHR (0.39) | ADORA2ACNR1CNR2SMN1; SMN2L3MBTL1 | |
| SCHEMBL23666718 | 0.80 | IMPDH2 (0.48) | ADORA2AIMPDH2CNR1CNR2SMN1; SMN2 | |
| SCHEMBL33526939 | 0.80 | NAMPT (0.40) | RAB9AMEN1NPC1KMT2AGAA | |
| SCHEMBL24707465 | 0.78 | AAK1 (0.39) | ADORA2ARAB9AAAK1KDM4EATR | |
| SCHEMBL7269535 | 0.76 | AAK1 (0.41) | TSHRAAK1 | |
| SCHEMBL7275375 | 0.76 | AAK1 (0.41) | TSHRAAK1 | |
| SCHEMBL26790240 | 0.76 | IMPDH2 (0.45) | ADORA2AIMPDH2CNR1CNR2SMN1; SMN2 | |
| SCHEMBL1111315 | 0.76 | RAB9A (0.39) | ADORA2ASMN1; SMN2RAB9AMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8426448-B2 | 1,5-diphenyl-pyrrolidin-2-one compounds as CB-1 ligands | ELI LILLY AND COMPANY (US) | 2013-04-23 | — | — | US | disclosed |
| US-8426448-B2 | 1,5-diphenyl-pyrrolidin-2-one compounds as CB-1 ligands | ELI LILLY AND COMPANY (US) | 2013-04-23 | — | — | US | disclosed |
| US-8426448-B2 | 1,5-diphenyl-pyrrolidin-2-one compounds as CB-1 ligands | ELI LILLY AND COMPANY (US) | 2013-04-23 | — | — | US | disclosed |
| US-20110028520-A1 | 1,5-DIPHENYL-PYRROLIDIN-2-ONE COMPOUNDS AS CB-1 LIGANDS | ELI LILLY AND COMPANY (US) | 2011-02-03 | — | — | US | disclosed |
| US-20110028520-A1 | 1,5-DIPHENYL-PYRROLIDIN-2-ONE COMPOUNDS AS CB-1 LIGANDS | ELI LILLY AND COMPANY (US) | 2011-02-03 | — | — | US | disclosed |
| US-20110028520-A1 | 1,5-DIPHENYL-PYRROLIDIN-2-ONE COMPOUNDS AS CB-1 LIGANDS | ELI LILLY AND COMPANY (US) | 2011-02-03 | — | — | US | disclosed |
| EP-2278968-A2 | 1,5-DIPHENYL-PYRROLIDIN-2-ONE COMPOUNDS AS CB-1 LIGANDS | ELI LILLY AND COMPANY (US) | 2011-02-02 | — | — | EP | disclosed |
| WO-2009131814-A2 | 1,5-DIPHENYL-PYRROLIDIN-2-ONE COMPOUNDS AS CB-1 LIGANDS | ELI LILLY AND COMPANY (US) | 2009-10-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110028520-A1 | 1,5-DIPHENYL-PYRROLIDIN-2-ONE COMPOUNDS AS CB-1 LIGANDS | CNR1, CNR2, GPR119 | ADORA2A 445/4885IMPDH2 4158/4885CNR1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.