Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | KCNT1 | Q5JUK3 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11121167 | 0.92 | CYP2C19 (0.57) | ALDH1A1SMN1; SMN2GAATSHRMAPK1 | |
| SCHEMBL11113941 | 0.88 | SMN1; SMN2 (0.52) | ALDH1A1SMN1; SMN2GAATSHRMAPK1 | |
| SCHEMBL11120207 | 0.86 | CYP2C19 (0.58) | ALDH1A1GAATSHRCYP2C19MEN1 | |
| SCHEMBL11111875 | 0.81 | ALDH1A1 (0.50) | ALDH1A1SMN1; SMN2GAATSHRMAPK1 | |
| SCHEMBL11113958 | 0.77 | CYP2C19 (0.57) | ALDH1A1SMN1; SMN2GAACYP2C19MEN1 | |
| SCHEMBL11114414 | 0.76 | CYP2C19 (0.69) | ALDH1A1SMN1; SMN2GAATSHRKDM4E | |
| SCHEMBL11119188 | 0.75 | CYP2C19 (0.52) | ALDH1A1SMN1; SMN2GAACYP2C19MEN1 | |
| SCHEMBL11113875 | 0.75 | CYP2C19 (0.52) | ALDH1A1SMN1; SMN2GAACYP2C19MEN1 | |
| SCHEMBL11118092 | 0.73 | CYP2C19 (0.55) | ALDH1A1GAACYP2C19MEN1KMT2A | |
| SCHEMBL11117214 | 0.70 | HTT (0.51) | ALDH1A1SMN1; SMN2KDM4ECYP2C19MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0034415-B1 | 1-(CYCLOHEXYL OR CYCLOHEXENYL)-4-ARYL-4-PIPERIDINECARBOXYLIC ACID DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1984-05-30 | — | — | EP | disclosed |
| US-4369184-A | ANTIHISTAMINES; HETEROCYCLIC NITRILES | JANSSEN PHARMACEUTICA N.V. (BE) | 1983-01-18 | — | — | US | disclosed |
| EP-0034415-A1 | 1-(Cyclohexyl or cyclohexenyl)-4-aryl-4-piperidinecarboxylic acid derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1981-08-26 | — | — | EP | disclosed |