Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.52 |
| ▸ | HTR2A | P28223 | 3/20 | 0.50 |
| ▸ | HRH1 | P35367 | 3/20 | 0.50 |
| ▸ | CNR1 | P21554 | 1/20 | 0.50 |
| ▸ | CNR2 | P34972 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | MITF | O75030 | 1/20 | 0.49 |
| ▸ | CASR | P41180 | 2/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11111163 | 0.88 | HTR2A (0.63) | SIGMAR1KMT2AMEN1HTR2AHRH1 | |
| Hydrochloric Acid SCHEMBL11118179 | 0.87 | HTR2A (0.61) | SIGMAR1KMT2AMEN1HTR2AHRH1 | |
| Hydrochloric Acid SCHEMBL11114590 | 0.87 | HTR2A (0.61) | SIGMAR1KMT2AMEN1HTR2AHRH1 | |
| SCHEMBL11110461 | 0.81 | TSHR (0.59) | SIGMAR1KMT2AMEN1HTR2AHRH1 | |
| SCHEMBL11130111 | 0.79 | TSHR (0.57) | SIGMAR1KMT2AMEN1HTR2AHRH1 | |
| SCHEMBL11113464 | 0.74 | DRD2 (0.63) | KMT2AMEN1CNR1CNR2ALDH1A1 | |
| SCHEMBL16301227 | 0.74 | SLC6A2 (0.55) | KMT2AMEN1CNR1CNR2ALDH1A1 | |
| SCHEMBL11186559 | 0.72 | SLC6A4 (0.57) | KMT2AMEN1HTR2AHRH1MAPT | |
| SCHEMBL5268848 | 0.71 | SLC6A4 (0.82) | SIGMAR1KMT2AMEN1HTR2AHRH1 | |
| SCHEMBL9051194 | 0.71 | SIGMAR1 (1.00) | SIGMAR1HTR2AHRH1LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0041757-B1 | ETHYLENDIAMINE DERIVATIVES, PREPARATION THEREOF, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME AND INTERMEDIATES FOR THEIR PREPARATION | Simes S.p.A. (IT) | 1984-11-07 | — | — | EP | disclosed |
| EP-0041757-A1 | Ethylendiamine derivatives, preparation thereof, pharmaceutical compositions containing same and intermediates for their preparation | Simes S.p.A. (IT) | 1981-12-16 | — | — | EP | disclosed |