Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 8/20 | 0.36 |
| ▸ | DRD3 | P35462 | 7/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11113950 | 0.85 | SETD7 (0.39) | DRD2DRD4ABCB1MAPT | |
| SCHEMBL11591416 | 0.80 | DRD2 (0.38) | DRD2DRD3DRD4ESR1ESR2 | |
| SCHEMBL10956945 | 0.78 | SETD7 (0.50) | DRD2DRD3DRD4HTR2AHTR2C | |
| SCHEMBL11632788 | 0.78 | GAA (0.41) | DRD2DRD4ABCB1HTR2AHTR2C | |
| SCHEMBL11399919 | 0.77 | LMNA (0.45) | DRD2DRD3HRH3MAPT | |
| SCHEMBL11590250 | 0.74 | ALDH1A1 (0.46) | KDM4EMEN1ALDH1A1MAPTKMT2A | |
| Savoxepin SCHEMBL2110369 | 0.73 | DRD2 (0.40) | DRD2DRD3MEN1 | |
| SCHEMBL11399243 | 0.73 | CA12 (0.40) | ALDH1A1 | |
| SCHEMBL11400336 | 0.71 | LMNA (0.47) | DRD2DRD3MAPT | |
| SCHEMBL11088273 | 0.70 | GSK3B (0.36) | HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0007450-A1 | Azatetracyclic carbonitriles, their preparation, pharmaceutical compositions containing them and their application | CIBA-GEIGY AG (CH) | 1980-02-06 | — | — | EP | claimed |
| EP-0125484-A1 | Polycyclic carboxylic-acid compounds, process for their production, preparations containing such carboxylic-acid compounds and their use | CIBA-GEIGY AG (CH) | 1984-11-21 | — | — | EP | disclosed |
| US-4263315-A | TRANQUILLIZERS; SEDATIVES; ANTAGONIST FOR STIMULANTS | CIBA-GEIGY CORPORATION (US) | 1981-04-21 | — | — | US | disclosed |
| EP-0007450-A1 | Azatetracyclic carbonitriles, their preparation, pharmaceutical compositions containing them and their application | CIBA-GEIGY AG (CH) | 1980-02-06 | — | — | EP | disclosed |