Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.47 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24262954 | 0.95 | F10 (0.48) | TP53HTTHIF1ANPSR1LMNA | |
| SCHEMBL7816033 | 0.90 | TP53 (0.48) | TP53HTTHIF1ANPSR1LMNA | |
| SCHEMBL1936616 | 0.90 | LMNA (0.49) | TP53HTTHIF1ANPSR1LMNA | |
| SCHEMBL5224872 | 0.86 | ALDH1A1 (0.61) | TP53HTTHIF1ANPSR1LMNA | |
| SCHEMBL609306 | 0.86 | TP53 (0.59) | TP53HTTHIF1ANPSR1LMNA | |
| SCHEMBL29930365 | 0.86 | TP53 (0.59) | TP53HTTHIF1ANPSR1LMNA | |
| SCHEMBL5218738 | 0.85 | KMT2A (0.53) | TP53HTTHIF1ANPSR1LMNA | |
| SCHEMBL11116125 | 0.85 | NPC1 (0.60) | TP53HTTHIF1ANPSR1KMT2A | |
| SCHEMBL20794654 | 0.84 | ALDH1A1 (0.51) | TP53HTTHIF1ANPSR1LMNA | |
| SCHEMBL1937159 | 0.84 | TP53 (0.46) | TP53HTTHIF1ANPSR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0106988-A1 | Pharmacologically active lactam derivatives | THE WELLCOME FOUNDATION LIMITED (GB) | 1984-05-02 | — | — | EP | claimed |
| US-11124503-B2 | Compositions and methods for acylating lactams | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2021-09-21 | — | — | US | disclosed |
| US-11124503-B2 | Compositions and methods for acylating lactams | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2021-09-21 | — | — | US | disclosed |
| US-20190077796-A1 | COMPOSITIONS AND METHODS FOR ACYLATING LACTAMS | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2019-03-14 | — | — | US | disclosed |
| US-20190077796-A1 | COMPOSITIONS AND METHODS FOR ACYLATING LACTAMS | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2019-03-14 | — | — | US | disclosed |
| EP-3426391-A1 | COMPOSITIONS AND METHODS FOR ACYLATING LACTAMS | California Institute of Technology (US) | 2019-01-16 | — | — | EP | disclosed |
| US-10040784-B2 | Compositions and methods for acylating lactams | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2018-08-07 | — | — | US | disclosed |
| US-10040784-B2 | Compositions and methods for acylating lactams | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2018-08-07 | — | — | US | disclosed |
| US-20170260172-A1 | COMPOSITIONS AND METHODS FOR ACYLATING LACTAMS | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2017-09-14 | — | — | US | disclosed |
| US-20170260172-A1 | COMPOSITIONS AND METHODS FOR ACYLATING LACTAMS | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2017-09-14 | — | — | US | disclosed |
| WO-2017156239-A1 | COMPOSITIONS AND METHODS FOR ACYLATING LACTAMS | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2017-09-14 | — | — | WO | disclosed |
| EP-0106988-A1 | Pharmacologically active lactam derivatives | THE WELLCOME FOUNDATION LIMITED (GB) | 1984-05-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11124503-B2 | Compositions and methods for acylating lactams | COASY, ASNS, NAAA | TP53 4788/4885HTT 3751/4885HIF1A 4346/4885 |
| US-20170260172-A1 | COMPOSITIONS AND METHODS FOR ACYLATING LACTAMS | COASY, NAAA, ASNS | TP53 4661/4885HTT 2062/4885HIF1A 4652/4885 |
| US-10040784-B2 | Compositions and methods for acylating lactams | COASY, NAAA, ASNS | TP53 4661/4885HTT 2062/4885HIF1A 4652/4885 |
| US-20190077796-A1 | COMPOSITIONS AND METHODS FOR ACYLATING LACTAMS | COASY, NAAA, ASNS | TP53 4661/4885HTT 2062/4885HIF1A 4652/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.