Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.59 |
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | THRB | P10828 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | BLM | P54132 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | F10 | P00742 | 5/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29930365 | 1.00 | TP53 (0.59) | TP53POLBHTTHIF1ANPSR1 | |
| SCHEMBL611715 | 0.95 | F10 (0.57) | TP53POLBHTTHIF1ANPSR1 | |
| SCHEMBL608919 | 0.93 | F10 (0.58) | TP53POLBHTTHIF1ANPSR1 | |
| SCHEMBL2046118 | 0.89 | POLB (0.61) | TP53POLBHTTHIF1ANPSR1 | |
| SCHEMBL14217341 | 0.86 | GAA (0.67) | TP53HTTHIF1ANPSR1ALDH1A1 | |
| SCHEMBL11116902 | 0.86 | TP53 (0.52) | TP53POLBHTTHIF1ANPSR1 | |
| SCHEMBL11142367 | 0.84 | ALDH1A1 (0.74) | TP53ALDH1A1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL8121115 | 0.82 | ALDH1A1 (0.57) | TP53HTTHIF1ANPSR1ALDH1A1 | |
| SCHEMBL25094272 | 0.81 | LIPE (0.53) | TP53POLBHTTHIF1ANPSR1 | |
| SCHEMBL25094195 | 0.81 | ALDH1A1 (0.53) | TP53HTTHIF1ANPSR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 186 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102239146-A | Novel compounds as calcium channel blockers | ABBOTT LAB | 2011-11-09 | — | — | CN | claimed |
| US-4115205-A | Separation of phenol-, cyclohexanone-, and cyclohexylbenzene-containing mixtures employing an N-substituted lactam | PHILLIPS PETROLEUM COMPANY (US) | 1978-09-19 | — | — | US | claimed |
| US-20250214995-A1 | CONDENSED BICYCLIC HETEROAROMATIC COMPOUNDS AND THEIR USE IN THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2025-07-03 | — | — | US | disclosed |
| US-12338240-B2 | Nonmuscle myosin ii inhibitors | THE UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2025-06-24 | — | — | US | disclosed |
| US-20250163056-A1 | NONMUSCLE MYOSIN II INHIBITORS | THE UNIV OF FLORIDA RESEARCH FOUNDATION INC (US) | 2025-05-22 | — | — | US | disclosed |
| EP-4514793-A1 | CONDENSED BICYCLIC HETEROAROMATIC COMPOUNDS AND THEIR USE IN THE TREATMENT OF CANCER | Astrazeneca AB (SE) | 2025-03-05 | — | — | EP | disclosed |
| US-11912708-B2 | Macrocyclic heterocycles and uses thereof | KUMQUAT BIOSCIENCES INC. (US) | 2024-02-27 | — | — | US | disclosed |
| US-11912708-B2 | Macrocyclic heterocycles and uses thereof | KUMQUAT BIOSCIENCES INC. (US) | 2024-02-27 | — | — | US | disclosed |
| EP-4289883-A1 | CURABLE RESIN COMPOSITION | ADEKA CORPORATION (JP) | 2023-12-13 | — | — | EP | disclosed |
| WO-2023209084-A1 | CONDENSED BICYCLIC HETEROAROMATIC COMPOUNDS AND THEIR USE IN THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2023-11-02 | — | — | WO | disclosed |
| WO-2023205701-A1 | MACROCYCLIC HETEROCYCLES AND USES THEREOF | KUMQUAT BIOSCIENCES INC. (US) | 2023-10-26 | — | — | WO | disclosed |
| CN-1248291-A | Phosphodiesterase 8A | ICOS CORP (US) | 2000-03-22 | — | — | CN | disclosed |
| US-6004974-A | PHOSPHODIESTERASE AND TUMOR NECROSIS FACTOR INHIBITORS; ANTIINFLAMMATORY AND ANTIASTHMA AGENTS | PFIZER INC (US) | 1999-12-21 | — | — | US | disclosed |
| EP-0837860-A1 | TRICYCLIC 5,6-DIHYDRO-9H-PYRAZOLO 3,4-c]-1,2,4-TRIAZOLO 4,3-$g(a)]PYRIDINES | PFIZER INC. (US) | 1998-04-29 | — | — | EP | disclosed |
| WO-1996039408-A1 | TRICYCLIC 5,6-DIHYDRO-9H-PYRAZOLO[3,4-c]-1,2,4-TRIAZOLO[4,3-α]PYRIDINES | PFIZER INC. (US) | 1996-12-12 | — | — | WO | disclosed |
| EP-0350437-B1 | 3,4-Disubstituted phenyl-heterocycles and their use | SCHERING AG (DE) | 1995-09-06 | — | — | EP | disclosed |
| US-5064854-A | 3,4-DISUBSTITUTED PHENYL HETEROCYCLES AND THEIR USE | SCHERING AKTIENGESELLSCHAFT (DE) | 1991-11-12 | — | — | US | disclosed |
| US-5001196-A | Process for preparation of diene type polymer rubber | NIPPON ZEON CO., LTD. (JP) | 1991-03-19 | — | — | US | disclosed |
| EP-0350437-A1 | 3,4-Disubstituted phenyl-heterocycles and their use | SCHERING AKTIENGESELLSCHAFT (DE) | 1990-01-10 | — | — | EP | disclosed |
| US-4115205-A | Separation of phenol-, cyclohexanone-, and cyclohexylbenzene-containing mixtures employing an N-substituted lactam | PHILLIPS PETROLEUM COMPANY (US) | 1978-09-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11912708-B2 | Macrocyclic heterocycles and uses thereof | HRAS, KRAS, TP53 | TP53 3/4885POLB 2260/4885HTT 476/4885 |
| US-20250163056-A1 | NONMUSCLE MYOSIN II INHIBITORS | MYH2, MYO3B, MYO1B | TP53 4302/4885POLB 88/4885HTT 3379/4885 |
| US-20250214995-A1 | CONDENSED BICYCLIC HETEROAROMATIC COMPOUNDS AND THEIR USE IN THE TREATMENT OF CANCER | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, TP53, SDHA | TP53 2/4885POLB 213/4885HTT 1377/4885 |
| US-12338240-B2 | Nonmuscle myosin ii inhibitors | MYH2, MYO3B, MYO1B | TP53 4302/4885POLB 88/4885HTT 3379/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.