Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 2/20 | 0.39 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.38 |
| ▸ | HK1 | P19367 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.37 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11115373 | 0.87 | HTR2B (0.46) | HTTHTR2BTMEM97HTR1AHTR7 | |
| SCHEMBL11117377 | 0.85 | HTR2A (0.42) | LMNAHTR2AHTR2CHRH1POLB | |
| SCHEMBL11117418 | 0.76 | MAPT (0.46) | LMNAHTR2BHTR1AHTR7HTR2A | |
| SCHEMBL11112033 | 0.76 | MEN1 (0.39) | HTR2AHTR2CHRH1MEN1KMT2A | |
| SCHEMBL11111188 | 0.74 | ALDH1A1 (0.41) | HTR2AHTR2CHRH1ALDH1A1TSHR | |
| SCHEMBL10863210 | 0.69 | HTR2A (0.52) | LMNAHTTHTR1ASIGMAR1HTR2A | |
| SCHEMBL15743329 | 0.66 | SLC18A3 (0.64) | LMNAHTTHTR1AHTR7POLB | |
| Hydrochloric Acid SCHEMBL9455315 | 0.65 | CNR1 (0.38) | HTTALDH1A1MEN1KMT2A | |
| SCHEMBL7682336 | 0.65 | P2RX7 (0.52) | HTTHTR1AHTR2CPOLBALDH1A1 | |
| SCHEMBL11115905 | 0.64 | DRD2 (0.37) | HTR2BHTR1AHTR2AHTR2CMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0038564-B1 | DIBENZ (B,E) OXEPIN DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | KYOWA HAKKO KOGYO CO., LTD (JP) | 1984-09-12 | — | — | EP | disclosed |
| US-4396550-A | ANTICHOLINERGIC, ANTIHISTIMINIC AGENTS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1983-08-02 | — | — | US | disclosed |
| EP-0038564-A1 | Dibenz (b,e) oxepin derivatives and pharmaceutical compositions comprising them | KYOWA HAKKO KOGYO CO., LTD (JP) | 1981-10-28 | — | — | EP | disclosed |