Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 4/20 | 0.57 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.57 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.57 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.57 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.45 |
| ▸ | IDO1 | P14902 | 2/20 | 0.42 |
| ▸ | CACNA2D1 | P54289 | 3/20 | 0.41 |
| ▸ | CACNA1B | Q00975 | 3/20 | 0.41 |
| ▸ | CACNB1 | Q02641 | 3/20 | 0.41 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7054929 | 0.86 | OPRM1 (0.63) | OPRM1OPRD1OPRK1OPRL1CYP17A1 | |
| SCHEMBL8124509 | 0.81 | OPRD1 (0.57) | OPRM1OPRD1OPRK1OPRL1CYP17A1 | |
| SCHEMBL12508362 | 0.81 | OPRM1 (0.57) | OPRM1OPRD1OPRK1OPRL1CYP17A1 | |
| SCHEMBL645116 | 0.78 | OPRM1 (0.45) | OPRM1OPRD1OPRK1OPRL1CACNA2D1 | |
| SCHEMBL28554103 | 0.77 | OPRM1 (0.57) | OPRM1OPRD1OPRK1OPRL1CACNA2D1 | |
| SCHEMBL20804476 | 0.76 | ATM (0.52) | OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL492900 | 0.74 | OPRM1 (0.50) | OPRM1OPRD1OPRK1OPRL1IDO1 | |
| SCHEMBL20804659 | 0.74 | CHRM3 (0.60) | OPRM1OPRD1OPRK1OPRL1CYP1A2 | |
| SCHEMBL20804660 | 0.74 | MAOB (0.61) | OPRM1OPRD1OPRK1OPRL1CACNA2D1 | |
| SCHEMBL644900 | 0.73 | OPRM1 (0.49) | OPRM1OPRD1OPRK1OPRL1CACNA2D1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2279174-A2 | ARYLSULFONAMIDE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | Genentech, Inc. (US) | 2011-02-02 | — | — | EP | disclosed |
| WO-2009143246-A2 | ARYLSULFONAMIDE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | GENENTECH, INC. (US) | 2009-11-26 | — | — | WO | disclosed |