Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 6/20 | 0.57 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.57 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.57 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.53 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.53 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | IDO1 | P14902 | 2/20 | 0.42 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.42 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL26980890 | 0.88 | OPRD1 (0.56) | OPRD1OPRM1OPRK1OPRL1MEN1 | |
| Trifluoroacetic Acid SCHEMBL23293527 | 0.88 | OPRD1 (0.56) | OPRD1OPRM1OPRK1OPRL1MEN1 | |
| SCHEMBL7054929 | 0.86 | OPRM1 (0.63) | OPRD1OPRM1OPRK1OPRL1CACNA2D1 | |
| SCHEMBL30330203 | 0.84 | OPRM1 (0.57) | OPRD1OPRM1OPRK1OPRL1CACNA2D1 | |
| SCHEMBL3395013 | 0.84 | CACNA2D1 (0.57) | OPRD1OPRM1OPRK1OPRL1MEN1 | |
| SCHEMBL12508362 | 0.81 | OPRM1 (0.57) | OPRD1OPRM1OPRK1OPRL1MEN1 | |
| SCHEMBL1111708 | 0.81 | OPRM1 (0.57) | OPRD1OPRM1OPRK1OPRL1CACNA2D1 | |
| SCHEMBL3949161 | 0.79 | OPRM1 (0.49) | OPRD1OPRM1OPRK1OPRL1MEN1 | |
| SCHEMBL23802612 | 0.79 | OPRM1 (0.52) | OPRD1OPRM1OPRK1OPRL1CACNA2D1 | |
| SCHEMBL493178 | 0.78 | CACNA2D1 (0.61) | OPRD1OPRM1OPRK1OPRL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112585139-B | Naphthyridinone compounds as T cell activators | 百时美施贵宝公司 | 2023-12-01 | — | — | CN | disclosed |
| EP-3814347-B1 | NAPHTHYRIDINONE COMPOUNDS USEFUL AS T CELL ACTIVATORS | BRISTOL MYERS SQUIBB CO (US) | 2023-05-03 | — | — | EP | disclosed |
| US-20210277004-A1 | NAPHTHYRIDINONE COMPOUNDS USEFUL AS T CELL ACTIVATORS | BRISTOL MYERS SQUIBB CO (US) | 2021-09-09 | — | — | US | disclosed |
| CN-112585139-A | Nalidinone compounds as T cell activators | 百时美施贵宝公司 | 2021-03-30 | — | — | CN | disclosed |
| EP-0691962-B1 | 1-AMINO-3-PHENOXY PROPANE DERIVATIVES AS MODULATORS OF MULTI-DRUG RESISTANCE | BASF AG (DE) | 2000-09-13 | — | — | EP | disclosed |
| US-5622953-A | DRUG RESISTANT TO ANTICANCER CHEMOTHERAPEUTIC DRUG | BASF AKTIENGESELLSCHAFT (DE) | 1997-04-22 | — | — | US | disclosed |
| EP-0691962-A1 | 1-AMINO-3-PHENOXY PROPANE DERIVATIVES AS MODULATORS OF MULTI-DRUG RESISTANCE | BASF AKTIENGESELLSCHAFT (DE) | 1996-01-17 | — | — | EP | disclosed |
| WO-1994022842-A1 | 1-AMINO-3-PHENOXY PROPANE DERIVATIVES AS MODULATORS OF MULTI-DRUG RESISTANCE | BASF AKTIENGESELLSCHAFT (DE) | 1994-10-13 | — | — | WO | disclosed |
| US-4155935-A | Benzylamine analgesics | AMERICAN HOME PRODUCTS CORPORATION (US) | 1979-05-22 | — | — | US | disclosed |
| US-4021560-A | ANALGESICS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1977-05-03 | — | — | US | disclosed |
| US-4017637-A | Benzylamine analgesics | AMERICAN HOME PRODUCTS CORPORATION (US) | 1977-04-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210277004-A1 | NAPHTHYRIDINONE COMPOUNDS USEFUL AS T CELL ACTIVATORS | DGKZ, DGKA, DGKG | OPRD1 2243/4885OPRM1 4533/4885OPRK1 1455/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.