Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | GRK2 | P25098 | 1/20 | 0.51 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10876568 | 0.90 | CMA1 (0.56) | LMNASMN1; SMN2KMT2AALDH1A1KDM4E | |
| SCHEMBL11110045 | 0.86 | CMA1 (0.54) | LMNASMN1; SMN2KMT2AALDH1A1KDM4E | |
| SCHEMBL12445273 | 0.84 | LMNA (0.51) | LMNASMN1; SMN2KMT2AALDH1A1KDM4E | |
| SCHEMBL11110414 | 0.77 | ALDH1A1 (0.45) | LMNASMN1; SMN2KMT2AALDH1A1KDM4E | |
| SCHEMBL11118270 | 0.77 | CYP17A1 (0.46) | LMNASMN1; SMN2KMT2AALDH1A1KDM4E | |
| SCHEMBL11118161 | 0.77 | ALDH1A1 (0.45) | LMNASMN1; SMN2KMT2AALDH1A1KDM4E | |
| SCHEMBL11142367 | 0.76 | ALDH1A1 (0.74) | SMN1; SMN2ALDH1A1HPGDCYP1A2CYP3A4 | |
| SCHEMBL11082663 | 0.74 | ALDH1A1 (0.45) | LMNASMN1; SMN2KMT2AALDH1A1KDM4E | |
| SCHEMBL11082661 | 0.74 | ALDH1A1 (0.45) | LMNASMN1; SMN2KMT2AALDH1A1KDM4E | |
| SCHEMBL11114977 | 0.74 | ALDH1A1 (0.52) | SMN1; SMN2KMT2AGRK2CTDSP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0106988-A1 | Pharmacologically active lactam derivatives | THE WELLCOME FOUNDATION LIMITED (GB) | 1984-05-02 | — | — | EP | claimed |
| EP-0106988-A1 | Pharmacologically active lactam derivatives | THE WELLCOME FOUNDATION LIMITED (GB) | 1984-05-02 | — | — | EP | disclosed |