Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.51 |
| ▸ | HSD11B1 | P28845 | 9/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | CCR2 | P41597 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | AKT1 | P31749 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4432360 | 0.98 | DRD2 (0.50) | DRD2HSD11B1DRD3HDAC4CCR2 | |
| SCHEMBL7317540 | 0.84 | DRD3 (0.47) | HSD11B1DRD3OPRM1TSHRSMN1; SMN2 | |
| SCHEMBL5356989 | 0.84 | OPRM1 (0.57) | HDAC4OPRM1TSHRSMN1; SMN2 | |
| SCHEMBL3520379 | 0.84 | HSD11B1 (0.58) | HSD11B1DRD3HDAC4 | |
| Hydrochloric Acid SCHEMBL7624556 | 0.83 | OPRM1 (0.56) | OPRM1TSHRSMN1; SMN2 | |
| SCHEMBL652508 | 0.82 | DRD2 (0.56) | DRD2HSD11B1HDAC4CCR2OPRM1 | |
| SCHEMBL27594934 | 0.82 | DRD2 (0.59) | DRD2HSD11B1HDAC4OPRM1AKT1 | |
| SCHEMBL4005636 | 0.80 | DRD2 (0.58) | DRD2HSD11B1HDAC4OPRM1AKT1 | |
| SCHEMBL8226666 | 0.80 | OPRM1 (0.59) | HSD11B1DRD3OPRM1TSHRSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL4451578 | 0.79 | DRD2 (0.56) | DRD2HSD11B1HDAC4OPRM1AKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8759342-B2 | Benzo[1,4]oxazin-3-one, benzo[1,4]thiazin-3-one and quinolin-2-one urotensin II receptor antagonists | JANSSEN PHARMACEUTICA NV (BE) | 2014-06-24 | — | — | US | disclosed |
| US-8759342-B2 | Benzo[1,4]oxazin-3-one, benzo[1,4]thiazin-3-one and quinolin-2-one urotensin II receptor antagonists | JANSSEN PHARMACEUTICA NV (BE) | 2014-06-24 | — | — | US | disclosed |
| EP-0034415-B1 | 1-(CYCLOHEXYL OR CYCLOHEXENYL)-4-ARYL-4-PIPERIDINECARBOXYLIC ACID DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1984-05-30 | — | — | EP | disclosed |
| US-4369184-A | ANTIHISTAMINES; HETEROCYCLIC NITRILES | JANSSEN PHARMACEUTICA N.V. (BE) | 1983-01-18 | — | — | US | disclosed |
| EP-0034415-A1 | 1-(Cyclohexyl or cyclohexenyl)-4-aryl-4-piperidinecarboxylic acid derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1981-08-26 | — | — | EP | disclosed |