Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 2/20 | 0.61 |
| ▸ | TACR1 | P25103 | 2/20 | 0.61 |
| ▸ | CTSL | P07711 | 2/20 | 0.60 |
| ▸ | CTSB | P07858 | 2/20 | 0.60 |
| ▸ | CTSS | P25774 | 2/20 | 0.60 |
| ▸ | CTSK | P43235 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.57 |
| ▸ | CASP1 | P29466 | 3/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11119660 | 1.00 | ACE (0.61) | ACETACR1CTSLCTSBCTSS | |
| SCHEMBL11119658 | 1.00 | ACE (0.61) | ACETACR1CTSLCTSBCTSS | |
| SCHEMBL28356104 | 0.89 | TACR1 (0.64) | TACR1CTSLCTSBCTSSCTSK | |
| SCHEMBL11275140 | 0.88 | ALDH1A1 (0.61) | ACETACR1CTSLCTSBCTSS | |
| SCHEMBL6330507 | 0.84 | TACR1 (0.62) | TACR1CTSLCTSBCTSSCTSK | |
| SCHEMBL13998432 | 0.84 | CTSL (0.64) | TACR1CTSLCTSBCTSSCTSK | |
| SCHEMBL4980616 | 0.84 | TACR1 (0.62) | ACETACR1CTSLCTSBCTSS | |
| SCHEMBL7327386 | 0.84 | TACR1 (0.62) | TACR1CTSLCTSBCTSSCTSK | |
| SCHEMBL6439753 | 0.84 | TACR1 (0.62) | ACETACR1CTSLCTSBCTSS | |
| SCHEMBL7490981 | 0.84 | TACR1 (0.62) | ACETACR1CTSLCTSBCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0045161-B1 | AMIDES OF 4-OXO-5-AMIDOHEXANOIC ACID DERIVATIVES | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1984-03-14 | — | — | EP | disclosed |
| US-4329473-A | HYPOTENSIVE AGENTS | SRI INTERNATIONAL | 1982-05-11 | — | — | US | disclosed |
| EP-0045161-A1 | Amides of 4-oxo-5-amidohexanoic acid derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1982-02-03 | — | — | EP | disclosed |