Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.57 |
| ▸ | RECQL | P46063 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.51 |
| ▸ | PTPRF | P10586 | 1/20 | 0.50 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.50 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | IDO1 | P14902 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9823345 | 0.83 | MAPT (1.00) | MAPTALDH1A1HSD17B10RECQLSMN1; SMN2 | |
| SCHEMBL5516694 | 0.83 | MAPT (0.69) | MAPTALDH1A1HSD17B10RECQLSMN1; SMN2 | |
| SCHEMBL10614889 | 0.81 | MAPT (0.58) | MAPTALDH1A1HSD17B10RECQLSMN1; SMN2 | |
| SCHEMBL570831 | 0.80 | MAPT (1.00) | MAPTALDH1A1HSD17B10RECQLSMN1; SMN2 | |
| SCHEMBL6251043 | 0.80 | MAPT (0.66) | MAPTALDH1A1HSD17B10RECQLSMN1; SMN2 | |
| SCHEMBL4955548 | 0.79 | MAPT (0.70) | MAPTALDH1A1HSD17B10RECQLSMN1; SMN2 | |
| SCHEMBL9003269 | 0.79 | MAPT (0.70) | MAPTALDH1A1HSD17B10RECQLSMN1; SMN2 | |
| SCHEMBL11118915 | 0.79 | SMN1; SMN2 (0.55) | MAPTALDH1A1SMN1; SMN2MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL1405413 | 0.78 | MAPT (0.96) | MAPTALDH1A1HSD17B10RECQLSMN1; SMN2 | |
| Bromide SCHEMBL28010281 | 0.78 | MAPT (0.96) | MAPTALDH1A1HSD17B10RECQLSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0030846-B1 | PHARMACOLOGICALLY ACTIVE PEPTIDES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ELI LILLY AND COMPANY (US) | 1984-05-09 | — | — | EP | disclosed |
| EP-0030846-A2 | Pharmacologically active peptides, their preparation and pharmaceutical compositions containing them | ELI LILLY AND COMPANY (US) | 1981-06-24 | — | — | EP | disclosed |
| US-4251439-A | ENKEPHALIN ANALOGS AS ANALGESICS | ELI LILLY AND COMPANY (US) | 1981-02-17 | — | — | US | disclosed |