Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 9/20 | 0.68 |
| ▸ | AR | P10275 | 5/20 | 0.68 |
| ▸ | ABCB11 | O95342 | 3/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.57 |
| ▸ | NR3C1 | P04150 | 7/20 | 0.57 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | HTR1A | P08908 | 1/20 | 0.57 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.57 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.49 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11126077 | 1.00 | PGR (0.68) | PGRARABCB11CYP3A4NR3C1 | |
| SCHEMBL11127163 | 1.00 | PGR (0.68) | PGRARABCB11CYP3A4NR3C1 | |
| SCHEMBL10965348 | 0.92 | NR3C1 (0.59) | PGRARABCB11CYP3A4NR3C1 | |
| SCHEMBL10965356 | 0.92 | NR3C1 (0.59) | PGRARABCB11CYP3A4NR3C1 | |
| SCHEMBL11122309 | 0.91 | ABCB11 (0.71) | PGRARABCB11CYP3A4NR3C1 | |
| SCHEMBL11125527 | 0.91 | ABCB11 (0.71) | PGRARABCB11CYP3A4NR3C1 | |
| SCHEMBL11122299 | 0.91 | ABCB11 (0.71) | PGRARABCB11CYP3A4NR3C1 | |
| SCHEMBL11126579 | 0.89 | PGR (0.72) | PGRARABCB11CYP3A4NR3C1 | |
| SCHEMBL11236322 | 0.89 | PGR (0.72) | PGRARABCB11CYP3A4NR3C1 | |
| SCHEMBL11236326 | 0.89 | PGR (0.72) | PGRARABCB11CYP3A4NR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0029924-B1 | 6-ALPHA-FLUORO-16-METHYL-PREDNISOLONE-17,21 DIESTERS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | STEROSYNT Ltd. (GB) | 1984-08-15 | — | — | EP | disclosed |
| US-4358445-A | ANTIINFLAMMATORY AGENT | STEROSYNT LTD. (GB) | 1982-11-09 | — | — | US | disclosed |
| EP-0029924-A1 | 6-Alpha-fluoro-16-methyl-prednisolone-17,21 diesters and pharmaceutical compositions containing them | STEROSYNT Ltd. (GB) | 1981-06-10 | — | — | EP | disclosed |
| US-3998701-A | Process for the preparation of 17-acyl esters of 17α, 21-dihydroxysteroids of the pregnane series and novel products | LARK S.P.A. (IT) | 1976-12-21 | — | — | US | disclosed |