SCHEMBL11136337

SCHEMBL11136337

Cc1cccc(Cl)c1NC(=S)NC(=N)N

nearest known ligand 0.68

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
GAA P10253 3/20 0.68
MEN1 O00255 1/20 0.48
KMT2A Q03164 1/20 0.48
ALDH1A1 P00352 3/20 0.48
MAPT P10636 1/20 0.48
SMN1; SMN2 Q16637 1/20 0.48
PDK1 Q15118 1/20 0.43
PDK2 Q15119 1/20 0.43
PDK3 Q15120 1/20 0.43
PDK4 Q16654 1/20 0.43
BCHE P06276 1/20 0.42
LMNA P02545 2/20 0.41
CYP1A2 P05177 1/20 0.41
CYP3A4 P08684 1/20 0.41
CYP2C9 P11712 1/20 0.41
ALOX12 P18054 1/20 0.41
CYP2C19 P33261 1/20 0.41
POLB P06746 2/20 0.40
ATM Q13315 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11051530 0.89 GAA (0.50) GAAMEN1KMT2AALDH1A1MAPT
SCHEMBL11074940 0.89 GAA (0.50) GAAMEN1KMT2AALDH1A1MAPT
SCHEMBL4099012 0.84 GAA (0.54) GAAMEN1KMT2APDK1PDK2
Hydrochloric Acid SCHEMBL11141191 0.82 GAA (0.60) GAAMEN1KMT2AALDH1A1MAPT
SCHEMBL11136335 0.82 ALDH1A1 (0.46) GAAALDH1A1MAPTSMN1; SMN2LMNA
SCHEMBL11135124 0.82 LMNA (0.48) GAAALDH1A1MAPTSMN1; SMN2LMNA
SCHEMBL11140985 0.82 GAA (0.44) GAAMEN1KMT2AALDH1A1MAPT
SCHEMBL11138222 0.82 GAA (0.44) GAAMEN1KMT2AALDH1A1MAPT
SCHEMBL7168272 0.82 DRD2 (0.55) GAAPDK1PDK2PDK3PDK4
SCHEMBL11139027 0.81 GAA (0.44) GAAKMT2AALDH1A1SMN1; SMN2LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4418209-A ANTIULCER, ANTIARRYTHMIC, ANTIDIARRHEAL, ANTISPASMODIC, ANTIPARASITIC, AND ANTISECRETORY AGENTS WILLIAM H. RORER, INC. (US) 1983-11-29 US disclosed