Known targets — ChEMBL curated mechanism
GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQ
The experimentally established mechanism targets of Flunitrazepam. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 known ✓ | P14867 | 10/20 | 0.85 |
| ▸ | GABRA5 known ✓ | P31644 | 10/20 | 0.85 |
| ▸ | GABRA3 known ✓ | P34903 | 9/20 | 0.85 |
| ▸ | GABRA2 known ✓ | P47869 | 9/20 | 0.85 |
| ▸ | GABRG2 known ✓ | P18507 | 8/20 | 0.85 |
| ▸ | GABRB3 known ✓ | P28472 | 8/20 | 0.85 |
| ▸ | GABRB2 known ✓ | P47870 | 7/20 | 0.85 |
| ▸ | GABRP known ✓ | O00591 | 2/20 | 0.42 |
| ▸ | GABRD known ✓ | O14764 | 2/20 | 0.42 |
| ▸ | GABRB1 known ✓ | P18505 | 2/20 | 0.42 |
| ▸ | GABRA4 known ✓ | P48169 | 2/20 | 0.42 |
| ▸ | GABRE known ✓ | P78334 | 2/20 | 0.42 |
| ▸ | GABRA6 known ✓ | Q16445 | 2/20 | 0.42 |
| ▸ | GABRG1 known ✓ | Q8N1C3 | 2/20 | 0.42 |
| ▸ | GABRG3 known ✓ | Q99928 | 2/20 | 0.42 |
| ▸ | GABRQ known ✓ | Q9UN88 | 2/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.85 |
| ▸ | GHSR | Q92847 | 2/20 | 0.85 |
| ▸ | CCKBR | P32239 | 2/20 | 0.85 |
| ▸ | MC3R | P41968 | 1/20 | 0.85 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Flunitrazepam SCHEMBL29372584 | 0.92 | GABRA1 (1.00) | GABRA1GABRA5GABRA3GABRA2GABRG2 | |
| Flunitrazepam SCHEMBL44169 | 0.92 | GABRA1 (1.00) | GABRA1GABRA5GABRA3GABRA2GABRG2 | |
| Flunitrazepam SCHEMBL8812488 | 0.92 | GABRA1 (1.00) | GABRA1GABRA5GABRA3GABRA2GABRG2 | |
| Flunitrazepam SCHEMBL29902314 | 0.92 | GABRA1 (1.00) | GABRA1GABRA5GABRA3GABRA2GABRG2 | |
| Flunitrazepam SCHEMBL16922172 | 0.92 | GABRA1 (1.00) | GABRA1GABRA5GABRA3GABRA2GABRG2 | |
| Flunitrazepam SCHEMBL27607836 | 0.87 | GABRA1 (0.90) | GABRA1GABRA5GABRA3GABRA2GABRG2 | |
| Flunitrazepam SCHEMBL6703617 | 0.87 | GABRA1 (0.90) | GABRA1GABRA5GABRA3GABRA2GABRG2 | |
| Flunitrazepam SCHEMBL1900353 | 0.83 | GABRA1 (0.80) | GABRA1GABRA5GABRA3GABRA2GABRG2 | |
| Flunitrazepam SCHEMBL28086646 | 0.82 | GABRA1 (0.75) | GABRA1GABRA5GABRA3GABRA2GABRG2 | |
| Flunitrazepam SCHEMBL1831358 | 0.80 | GABRA1 (0.73) | GABRA1GABRA5GABRA3GABRA2GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0021337-B1 | PREPARATIONS FOR PARENTERAL ADMINISTRATION OF FAT-SOLUBLE DRUGS | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1983-12-07 | — | — | EP | disclosed |
| EP-0021337-A2 | Preparations for parenteral administration of fat-soluble drugs | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1981-01-07 | — | — | EP | disclosed |