Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4215300 | 0.92 | — | — | |
| SCHEMBL1114368 | 0.83 | ALDH1A1 (0.35) | ALDH1A1LMNAMAPTCNR1HTT | |
| SCHEMBL6533266 | 0.73 | BCL2L1 (0.31) | — | |
| SCHEMBL4893204 | 0.68 | BCL2L1 (0.35) | CA12CA1CA2CA9 | |
| SCHEMBL1114262 | 0.58 | CA2 (0.40) | CA12CA1CA2CA9ALDH1A1 | |
| SCHEMBL6846833 | 0.56 | PTGS1 (0.34) | — | |
| SCHEMBL14094466 | 0.51 | CA1 (0.56) | CA1CA2ALDH1A1LMNA | |
| SCHEMBL31219603 | 0.51 | MAPT (0.60) | CA12CA1CA2CA9MAPT | |
| Nitrobenzene SCHEMBL8084891 | 0.51 | ALDH1A1 (0.70) | CA12CA1CA2CA9ALDH1A1 | |
| SCHEMBL3971671 | 0.50 | SMN1; SMN2 (0.74) | CA12CA2CA9ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2279174-A2 | ARYLSULFONAMIDE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | Genentech, Inc. (US) | 2011-02-02 | — | — | EP | disclosed |
| WO-2009143246-A2 | ARYLSULFONAMIDE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | GENENTECH, INC. (US) | 2009-11-26 | — | — | WO | disclosed |