Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 10/20 | 0.40 |
| ▸ | CA4 | P22748 | 10/20 | 0.40 |
| ▸ | CA12 | O43570 | 8/20 | 0.38 |
| ▸ | CA1 | P00915 | 8/20 | 0.38 |
| ▸ | CA3 | P07451 | 8/20 | 0.38 |
| ▸ | CA6 | P23280 | 8/20 | 0.38 |
| ▸ | CA7 | P43166 | 8/20 | 0.38 |
| ▸ | CA9 | Q16790 | 8/20 | 0.38 |
| ▸ | CA13 | Q8N1Q1 | 8/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 8/20 | 0.38 |
| ▸ | CA5B | Q9Y2D0 | 8/20 | 0.38 |
| ▸ | CA5A | P35218 | 7/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4215302 | 0.89 | HTT (0.42) | CA2CA4CA12CA1CA3 | |
| SCHEMBL1114369 | 0.81 | HTT (0.44) | CA2CA4ALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL4219323 | 0.73 | CA12 (0.37) | CA2CA4CA12CA6CA7 | |
| SCHEMBL6468837 | 0.73 | CA2 (0.38) | CA2CA4CA12CA1CA3 | |
| SCHEMBL1114110 | 0.71 | CA2 (0.36) | CA2CA4CA12CA1CA3 | |
| SCHEMBL11677839 | 0.68 | ALDH1A1 (0.58) | ALDH1A1CYP1A2CYP2C19CYP3A4CYP2C9 | |
| SCHEMBL8433529 | 0.65 | L3MBTL1 (0.39) | ALDH1A1CYP1A2CYP2C19CYP3A4CYP2C9 | |
| SCHEMBL6025517 | 0.63 | KMT2A (0.44) | CA2CA1CA9ALDH1A1MAPT | |
| SCHEMBL4707544 | 0.63 | PDE7A (0.48) | ALDH1A1CYP3A4HTTMAPTGAA | |
| SCHEMBL6530527 | 0.62 | KMT2A (0.41) | CA2CA9ALDH1A1CYP2C19CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2279174-A2 | ARYLSULFONAMIDE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | Genentech, Inc. (US) | 2011-02-02 | — | — | EP | disclosed |
| WO-2009143246-A2 | ARYLSULFONAMIDE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | GENENTECH, INC. (US) | 2009-11-26 | — | — | WO | disclosed |
| WO-2005049593-A2 | N-ACYLSULFONAMIDE APOPTOSIS PROMOTERS | ABBOTT LABORATORIES (US) | 2005-06-02 | — | — | WO | disclosed |