Known targets — ChEMBL curated mechanism
ABL1BMXBRAFBTKCHRNA4CHRNB2CSNK1EEGFRERBB2F10FLT1FLT3FLT4IGF1RINSRITKJAK3KDRKITOPRM1PARP1PARP2PDGFRBPIK3CDRAF1RETSLC18A2TECTXKdacAdacBdacCftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 3/20 | 0.41 |
| ▸ | CA12 | O43570 | 2/20 | 0.41 |
| ▸ | CA9 | Q16790 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SNCA | P37840 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4429977 | 0.90 | ALDH1A1 (0.44) | CYP2D6CYP1A2ALDH1A1LMNAKDM4E | |
| SCHEMBL550359 | 0.87 | CYP2D6 (0.47) | CYP2D6CYP1A2ALDH1A1LMNAKDM4E | |
| SCHEMBL6603272 | 0.86 | CYP2D6 (0.44) | CYP2D6CYP1A2ALDH1A1LMNAKDM4E | |
| SCHEMBL28977449 | 0.84 | SMN1; SMN2 (0.57) | CYP2D6CYP1A2LMNAKDM4ESMN1; SMN2 | |
| SCHEMBL5422817 | 0.83 | GAA (0.52) | CYP2D6CYP1A2ALDH1A1LMNAKDM4E | |
| Butane SCHEMBL27630383 | 0.83 | GAA (0.52) | CYP2D6CYP1A2ALDH1A1LMNAKDM4E | |
| SCHEMBL10749800 | 0.83 | GAA (0.52) | CYP2D6CYP1A2ALDH1A1LMNAKDM4E | |
| SCHEMBL11721219 | 0.82 | ALDH1A1 (0.43) | CYP2D6CYP1A2ALDH1A1LMNAKDM4E | |
| SCHEMBL28907916 | 0.81 | ALDH1A1 (0.42) | CYP2D6CYP1A2ALDH1A1LMNAKDM4E | |
| Propyne SCHEMBL28767946 | 0.81 | ALDH1A1 (0.52) | CYP2D6CYP1A2ALDH1A1LMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115894502-A | Modified enoate auxiliary agent, preparation method, modified enoate, modified nylon composition and modified nylon | 江苏扬农化工集团有限公司 | 2023-04-04 | — | — | CN | claimed |
| CN-115894502-A | Modified enoate auxiliary agent, preparation method, modified enoate, modified nylon composition and modified nylon | 江苏扬农化工集团有限公司 | 2023-04-04 | — | — | CN | disclosed |
| US-10821196-B2 | Substrate based PET imaging agents | SIEMENS MEDICAL SOLUTIONS USA, INC. (US) | 2020-11-03 | — | — | US | disclosed |
| US-10639608-B2 | System, device and method for preparing tracers and transferring materials during radiosynthesis | SIEMENS MEDICAL SOLUTIONS USA, INC. (US) | 2020-05-05 | — | — | US | disclosed |
| EP-2279011-B1 | SUBSTRATE BASED PET IMAGING AGENTS | SIEMENS MEDICAL SOLUTIONS USA INC (US) | 2017-10-25 | — | — | EP | disclosed |
| EP-2288388-B1 | ACHIEVEMENT OF HIGH THERAPEUTIC INDEX THROUGH MOLECULAR IMAGING GUIDED TARGETED DRUG TREATMENT | SIEMENS MEDICAL SOLUTIONS (US) | 2016-08-31 | — | — | EP | disclosed |
| EP-2799091-B1 | System, device and method for preparing tracers and transferring materials during radiosynthesis | LILLY CO ELI (US) | 2016-07-13 | — | — | EP | disclosed |
| US-20150182643-A1 | Novel Substrate Based PET Imaging Agents | SIEMENS MEDICAL SOLUTIONS USA, INC. | 2015-07-02 | — | — | US | disclosed |
| US-9005577-B2 | Substrate based PET imaging agents | SIEMENS MEDICAL SOLUTIONS USA, INC. (US) | 2015-04-14 | — | — | US | disclosed |
| EP-2799091-A2 | System, device and method for preparing tracers and transferring materials during radiosynthesis | Siemens Medical Solutions USA, Inc. (US) | 2014-11-05 | — | — | EP | disclosed |
| US-20120283490-A1 | System, Device and Method for Preparing Tracers and Transferring Materials During Radiosynthesis | SIEMENS MEDICAL SOLUTIONS USA, INC. (US) | 2012-11-08 | — | — | US | disclosed |
| US-8293206-B2 | Achievement of a high therapeutic index through molecular imaging guided targeted drug treatment | SIEMENS MEDICAL SOLUTIONS USA, INC. (US) | 2012-10-23 | — | — | US | disclosed |
| EP-2511006-A2 | System, device and method for preparing tracers and transferring materials during radiosynthesis | Siemens Medical Solutions USA, Inc. (US) | 2012-10-17 | — | — | EP | disclosed |
| EP-2288388-A1 | ACHIEVEMENT OF HIGH THERAPEUTIC INDEX THROUGH MOLECULAR IMAGING GUIDED TARGETED DRUG TREATMENT | Siemens Medical Solutions USA, Inc. (US) | 2011-03-02 | — | — | EP | disclosed |
| EP-2279011-A2 | SUBSTRATE BASED PET IMAGING AGENTS | Siemens Medical Solutions USA, Inc. (US) | 2011-02-02 | — | — | EP | disclosed |
| US-20100074910-A1 | Achievement of a high therapeutic index through molecular imaging guided targeted drug treatment | SIEMENS MEDICAL SOLUTIONS USA, INC. (US) | 2010-03-25 | — | — | US | disclosed |
| US-20100074843-A1 | Novel Substrate Based PET Imaging Agents | SIEMENS MEDICAL SOLUTIONS USA, INC. (US) | 2010-03-25 | — | — | US | disclosed |
| WO-2009148554-A1 | ACHIEVEMENT OF HIGH THERAPEUTIC INDEX THROUGH MOLECULAR IMAGING GUIDED TARGETED DRUG TREATMENT | SIEMENS MEDICAL SOLUTIONS USA, INC. (US) | 2009-12-10 | — | — | WO | disclosed |
| WO-2009134405-A2 | NOVEL SUBSTRATE BASED PET IMAGING AGENTS | SIEMENS MEDICAL SOLUTIONS USA, INC. (US) | 2009-11-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100074843-A1 | Novel Substrate Based PET Imaging Agents | MPI, PIGO, SLC35B2 | CYP2D6 3534/4885CYP1A2 2713/4885ALDH1A1 2429/4885 |
| US-20120283490-A1 | System, Device and Method for Preparing Tracers and Transferring Materials During Radiosynthesis | TERT, VHL, REV1 | CYP2D6 885/4885CYP1A2 1262/4885ALDH1A1 2010/4885 |
| US-10639608-B2 | System, device and method for preparing tracers and transferring materials during radiosynthesis | TERT, VHL, REV1 | CYP2D6 885/4885CYP1A2 1262/4885ALDH1A1 2010/4885 |
| US-10821196-B2 | Substrate based PET imaging agents | MPI, PIGO, SLC35B2 | CYP2D6 2352/4885CYP1A2 1495/4885ALDH1A1 2040/4885 |
| US-20150182643-A1 | Novel Substrate Based PET Imaging Agents | MPI, PIGO, SLC35B2 | CYP2D6 3534/4885CYP1A2 2713/4885ALDH1A1 2429/4885 |
| US-20100074910-A1 | Achievement of a high therapeutic index through molecular imaging guided targeted drug treatment | MKI67, CD47, CD68 | CYP2D6 4040/4885CYP1A2 4678/4885ALDH1A1 1748/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.