Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TNF | P01375 | 1/20 | 0.38 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.37 |
| ▸ | LPO | P22079 | 4/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11615942 | 0.78 | TNF (0.39) | LMNAL3MBTL1ALDH1A1TP53MAPT | |
| SCHEMBL2118407 | 0.74 | CA12 (0.49) | LMNAL3MBTL1ALDH1A1MAPTLPO | |
| SCHEMBL20696078 | 0.72 | CA12 (0.47) | LMNAL3MBTL1ALDH1A1MAPTLPO | |
| SCHEMBL11621562 | 0.72 | ALDH1A1 (0.48) | LMNAALDH1A1MAPTBCL2L1KDM4E | |
| SCHEMBL28828329 | 0.72 | ACHE (0.47) | LMNAALDH1A1TP53TNFBCL2L1 | |
| SCHEMBL10511129 | 0.71 | KDM4E (0.50) | LMNAL3MBTL1ALDH1A1TP53MAPT | |
| SCHEMBL2115772 | 0.71 | CA12 (0.44) | LMNAALDH1A1MAPTLPOCYP1A2 | |
| SCHEMBL2115310 | 0.70 | NOTUM (0.65) | LMNAL3MBTL1ALDH1A1MAPTLPO | |
| SCHEMBL2117087 | 0.70 | OXER1 (0.55) | LMNAL3MBTL1ALDH1A1TP53MAPT | |
| SCHEMBL23397297 | 0.69 | NOTUM (0.46) | LMNAL3MBTL1ALDH1A1LPOCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4382088-A | DIABETIC COMPLICATIONS, ALDOSE REDUCTASE INHIBITORS | AYERST, MCKENNA & HARRISON, INC. (CA) | 1983-05-03 | — | — | US | disclosed |