Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | LATS1 | O95835 | 1/20 | 0.44 |
| ▸ | LATS2 | Q9NRM7 | 1/20 | 0.44 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21401740 | 0.85 | TNF (0.49) | KDM4ELMNACYP3A4CYP2D6CYP1A2 | |
| SCHEMBL28643684 | 0.80 | LATS1 (0.42) | KDM4ELMNACYP3A4CYP2D6CYP1A2 | |
| SCHEMBL4025912 | 0.80 | KDM4E (0.49) | KDM4ELMNACYP3A4CYP2D6CYP1A2 | |
| SCHEMBL2359679 | 0.79 | KDM4E (0.47) | KDM4ELMNACYP3A4CYP2D6CYP1A2 | |
| SCHEMBL16484721 | 0.77 | CYP3A4 (0.49) | KDM4ELMNACYP3A4CYP2D6CYP1A2 | |
| SCHEMBL11140810 | 0.76 | PRKCZ (0.42) | KDM4ECYP3A4CYP2D6CYP1A2CYP2C9 | |
| Pyridine SCHEMBL31317041 | 0.76 | SIGMAR1 (0.50) | KDM4ELMNACYP3A4CYP2D6CYP1A2 | |
| SCHEMBL29555314 | 0.74 | SIGMAR1 (0.63) | KDM4ECYP2D6CYP1A2CYP2C19MAPT | |
| SCHEMBL29364795 | 0.74 | SIGMAR1 (0.63) | KDM4ECYP2D6CYP1A2CYP2C19MAPT | |
| SCHEMBL27737084 | 0.74 | SIGMAR1 (0.63) | KDM4ECYP2D6CYP1A2CYP2C19MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10864217-B2 | Use of inhibitor of apoptosis protein (IAP) antagonists in HIV therapy | Sanford Burnham Prebys Medical Discovery Institute (US) | 2020-12-15 | — | — | US | disclosed |
| US-20200121693-A1 | Use of Inhibitor of Apoptosis Protein (IAP) Antagonists in HIV Therapy | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE | 2020-04-23 | — | — | US | disclosed |
| US-9782408-B2 | Modulators of cystic fibrosis transmembrane conductance regulator | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2017-10-10 | — | — | US | disclosed |
| US-20170196862-A2 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2017-07-13 | — | — | US | disclosed |
| US-4396619-A | ANTIBIOTICS | ELI LILLY AND COMPANY (US) | 1983-08-02 | — | — | US | disclosed |
| US-4382932-A | Isoquinolinium substituted cephalosporins | ELI LILLY AND COMPANY (US) | 1983-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10864217-B2 | Use of inhibitor of apoptosis protein (IAP) antagonists in HIV therapy | API5, BIRC3, BIRC5 | KDM4E 3126/4885LMNA 2103/4885CYP3A4 4373/4885 |
| US-20200121693-A1 | Use of Inhibitor of Apoptosis Protein (IAP) Antagonists in HIV Therapy | API5, BIRC3, BIRC5 | KDM4E 3126/4885LMNA 2103/4885CYP3A4 4373/4885 |
| US-20170196862-A2 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | CFTR, SCNN1B, SLC26A4 | KDM4E 2973/4885LMNA 3018/4885CYP3A4 3432/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.