Known targets — ChEMBL curated mechanism
CHRM1CHRM2CHRM3CHRM4CHRM5SLC6A2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 4/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.62 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 5/20 | 0.46 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | PTGES | O14684 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11003760 | 0.90 | HTT (0.50) | HTTSMN1; SMN2FFAR1TDP1L3MBTL1 | |
| SCHEMBL10492043 | 0.89 | MMP2 (0.45) | HTTSMN1; SMN2TDP1L3MBTL1LMNA | |
| SCHEMBL760068 | 0.88 | LMNA (0.49) | HTTSMN1; SMN2LMNAMAPTKDM4E | |
| SCHEMBL52309 | 0.87 | MMP2 (0.46) | HTTSMN1; SMN2TDP1L3MBTL1LMNA | |
| Toliodium SCHEMBL2895872 | 0.86 | MMP2 (0.45) | HTTSMN1; SMN2TDP1L3MBTL1LMNA | |
| SCHEMBL64191 | 0.85 | HTT (0.43) | HTTSMN1; SMN2FFAR1L3MBTL1LMNA | |
| SCHEMBL5709615 | 0.84 | TDP1 (0.46) | HTTSMN1; SMN2TDP1LMNACYP2C9 | |
| SCHEMBL4444572 | 0.84 | HTT (0.56) | HTTSMN1; SMN2FFAR1TDP1L3MBTL1 | |
| SCHEMBL7892665 | 0.82 | ALDH1A1 (0.48) | HTTSMN1; SMN2L3MBTL1LMNAMMP13 | |
| Toliodium SCHEMBL2895871 | 0.82 | GAA (0.50) | SMN1; SMN2TDP1LMNACYP2C9CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4399071-A | Method for making diaryliodonium salts | GENERAL ELECTRIC COMPANY (US) | 1983-08-16 | — | — | US | disclosed |