Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.34 |
| ▸ | TTR | P02766 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11148698 | 1.00 | KCNH2 (0.40) | KCNH2MEN1KMT2ALMNAFFAR1 | |
| SCHEMBL11446079 | 0.87 | KCNH2 (0.43) | KCNH2KMT2ALMNA | |
| SCHEMBL11155733 | 0.87 | OPRD1 (0.37) | KCNH2LMNA | |
| SCHEMBL11156483 | 0.81 | MEN1 (0.40) | KCNH2MEN1KMT2AFFAR1MAPT | |
| SCHEMBL11156480 | 0.81 | MEN1 (0.40) | KCNH2MEN1KMT2AFFAR1MAPT | |
| SCHEMBL11148240 | 0.79 | OPRD1 (0.42) | MEN1KMT2ALMNA | |
| SCHEMBL11146934 | 0.78 | TBXAS1 (0.49) | MEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL11146930 | 0.78 | TBXAS1 (0.49) | MEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL11439870 | 0.76 | KCNH2 (0.39) | KCNH2KMT2ALMNASMN1; SMN2 | |
| SCHEMBL11149205 | 0.75 | FFAR1 (0.44) | KCNH2MEN1KMT2ALMNAFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0009683-B1 | BASIC PHENYL ETHERS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THE PREPARATION OF THESE ETHERS AND COMPOSITIONS | MERCK PATENT GmbH (DE) | 1983-08-10 | — | — | EP | disclosed |
| EP-0009683-A1 | Basic phenyl ethers, pharmaceutical compositions containing them and the preparation of these ethers and compositions | MERCK PATENT GmbH (DE) | 1980-04-16 | — | — | EP | disclosed |