Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dronabinol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 known ✓ | P21554 | 10/20 | 1.00 |
| ▸ | CNR2 | P34972 | 16/20 | 1.00 |
| ▸ | ABHD12 | Q8N2K0 | 3/20 | 1.00 |
| ▸ | ABHD6 | Q9BV23 | 3/20 | 1.00 |
| ▸ | FAAH | O00519 | 2/20 | 1.00 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 1.00 |
| ▸ | GPR55 | Q9Y2T6 | 2/20 | 1.00 |
| ▸ | NR1I2 | O75469 | 1/20 | 1.00 |
| ▸ | LDHA | P00338 | 1/20 | 1.00 |
| ▸ | GLRA1 | P23415 | 1/20 | 1.00 |
| ▸ | GPR183 | P32249 | 1/20 | 1.00 |
| ▸ | DRD3 | P35462 | 1/20 | 1.00 |
| ▸ | ENPP2 | Q13822 | 1/20 | 1.00 |
| ▸ | GPR18 | Q14330 | 1/20 | 1.00 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.86 |
| ▸ | HTR1A | P08908 | 1/20 | 0.86 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.86 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.86 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.86 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.86 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dronabinol SCHEMBL29390424 | 1.00 | CNR2 (1.00) | CNR2CNR1ABHD12ABHD6FAAH | |
| Dronabinol SCHEMBL13394311 | 1.00 | CNR2 (1.00) | CNR2CNR1ABHD12ABHD6FAAH | |
| Dronabinol SCHEMBL29349828 | 1.00 | CNR2 (1.00) | CNR2CNR1ABHD12ABHD6FAAH | |
| Dronabinol SCHEMBL11375978 | 1.00 | CNR2 (1.00) | CNR2CNR1ABHD12ABHD6FAAH | |
| Dronabinol SCHEMBL1227386 | 1.00 | CNR2 (1.00) | CNR2CNR1ABHD12ABHD6FAAH | |
| Dronabinol SCHEMBL13214137 | 1.00 | CNR2 (1.00) | CNR2CNR1ABHD12ABHD6FAAH | |
| Dronabinol SCHEMBL24702729 | 1.00 | CNR2 (1.00) | CNR2CNR1ABHD12ABHD6FAAH | |
| Dronabinol SCHEMBL3686519 | 1.00 | CNR2 (1.00) | CNR2CNR1ABHD12ABHD6FAAH | |
| Dronabinol SCHEMBL4609 | 1.00 | CNR2 (1.00) | CNR2CNR1ABHD12ABHD6FAAH | |
| Dronabinol SCHEMBL22705549 | 1.00 | CNR2 (1.00) | CNR2CNR1ABHD12ABHD6FAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 310 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1896389-B1 | METHOD FOR THE PRODUCTION OF DRONABINOL FROM CANNABIDIOL, USING A MOLECULAR SIEVE | BIONORICA ETHICS GMBH (DE) | 2015-09-23 | — | — | EP | claimed |
| US-8324408-B2 | Method for the preparation of dronabinol | BIONORICA AG | 2012-12-04 | — | — | US | claimed |
| US-20100210860-A1 | METHOD FOR THE PREPARATION OF DRONABINOL | BIONORICA AG (DE) | 2010-08-19 | — | — | US | claimed |
| EP-1896389-A1 | METHOD FOR THE PRODUCTION OF DRONABINOL FROM CANNABIDIOL, USING A MOLECULAR SIEVE | Bionorica AG (DE) | 2008-03-12 | — | — | EP | claimed |
| WO-2006136273-A1 | METHOD FOR THE PRODUCTION OF DRONABINOL FROM CANNABIDIOL, USING A MOLECULAR SIEVE | BIONORICA AG (DE) | 2006-12-28 | — | — | WO | claimed |
| US-12635625-B2 | Bioceramic and carbon-based hydroponic systems, methods and devices | MULTIPLE ENERGY TECHNOLOGIES LLC | 2026-05-26 | — | — | US | disclosed |
| US-12409131-B2 | Transdermal delivery of dronabinol | PIKE THERAPEUTICS USA, INC. (US) | 2025-09-09 | — | — | US | disclosed |
| US-12409132-B2 | Transdermal delivery of dronabinol | PIKE THERAPEUTICS USA, INC. (US) | 2025-09-09 | — | — | US | disclosed |
| EP-4585035-A1 | BIOCERAMIC AND CARBON-BASED HYDROPONIC SYSTEMS, METHODS AND DEVICES | Multiple Energy Technologies LLC (US) | 2025-07-16 | — | — | EP | disclosed |
| US-20250134013-A1 | BIOCERAMIC AND CARBON-BASED HYDROPONIC SYSTEMS, METHODS AND DEVICES | MULTIPLE ENERGY TECHNOLOGIES LLC | 2025-05-01 | — | — | US | disclosed |
| EP-3687280-B1 | METHOD OF GROWING A PLANT ON A SOIL SUBSTRATE COMPRISING BIOCERAMIC AND SOIL SUBSTRATE COMPRISING BIOCERAMIC | MULTIPLE ENERGY TECH LLC (US) | 2025-04-16 | — | — | EP | disclosed |
| US-20250108033-A1 | INSECT PRODUCTION SYSTEMS AND METHODS | INSECTERGY, LLC (US) | 2025-04-03 | — | — | US | disclosed |
| US-20040049059-A1 | Comminuted plant material is extracted with CO2 under supercritical pressure and temperature conditions | WILMINGTON TRUST, NATIONAL ASSOCIATION, AS COLLATERAL AGENT | 2004-03-11 | — | — | US | disclosed |
| EP-1326598-A1 | METHOD FOR PRODUCING AN EXTRACT FROM CANNABIS PLANT MATTER, CONTAINING A TETRAHYDROCANNABINOL AND A CANNABIDIOL AND CANNABIS EXTRACTS | Delta-9-Pharma GmbH (DE) | 2003-07-16 | — | — | EP | disclosed |
| US-6509005-B1 | Nonozone depleting stable aerosol; treating nausea and vomiting associated with chemotherapy; muscle spasticity, pain, anorexia associated with AIDS wasting syndrome, epilepsy, glaucoma, bronchial asthma and mood disorders | VIRGINIA COMMONWEALTH UNIVERSITY | 2003-01-21 | — | — | US | disclosed |
| WO-2002032420-A1 | METHOD FOR PRODUCING AN EXTRACT FROM CANNABIS PLANT MATTER, CONTAINING A TETRAHYDROCANNABINOL AND A CANNABIDIOL AND CANNABIS EXTRACTS | DELTA-9-PHARMA GMBH (DE) | 2002-04-25 | — | — | WO | disclosed |
| US-20020031480-A1 | Delta9 tetrahydrocannabinol (Delta9 THC) solution metered dose inhalers and methods of use | VIRGINIA COMMONWEALTH UNIVERSITY | 2002-03-14 | — | — | US | disclosed |
| EP-1124551-A2 | DELTA 9 TETRAHYDROCANNABINOL (DELTA 9 THC) SOLUTION METERED DOSE INHALERS AND METHODS OF USE | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 2001-08-22 | — | — | EP | disclosed |
| WO-2000024362-A2 | Δ9 TETRAHYDROCANNABINOL (Δ9 THC) SOLUTION METERED DOSE INHALERS AND METHODS OF USE | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 2000-05-04 | — | — | WO | disclosed |
| US-4438207-A | RADIOACTIVE IODINE LABELED | HOFFMANN-LA ROCHE INC. (US) | 1984-03-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250134013-A1 | BIOCERAMIC AND CARBON-BASED HYDROPONIC SYSTEMS, METHODS AND DEVICES | CNR2, GAP43, CNR1 | CNR1 3/4885CNR2 1/4885ABHD12 419/4885 |
| US-12409132-B2 | Transdermal delivery of dronabinol | CNR2, CNR1, OPRL1 | CNR1 2/4885CNR2 1/4885ABHD12 1531/4885 |
| US-12409131-B2 | Transdermal delivery of dronabinol | CNR2, CNR1, OPRL1 | CNR1 2/4885CNR2 1/4885ABHD12 1531/4885 |
| US-20250108033-A1 | INSECT PRODUCTION SYSTEMS AND METHODS | GSS, LSS, IPMK | CNR1 4824/4885CNR2 4715/4885ABHD12 306/4885 |
| US-20040049059-A1 | Comminuted plant material is extracted with CO2 under supercritical pressure and temperature conditions | CNR2, CNR1, FAAH | CNR1 2/4885CNR2 1/4885ABHD12 1012/4885 |
| US-12635625-B2 | Bioceramic and carbon-based hydroponic systems, methods and devices | CNR2, WNT1, CNR1 | CNR1 3/4885CNR2 1/4885ABHD12 638/4885 |
| US-20100210860-A1 | METHOD FOR THE PREPARATION OF DRONABINOL | CNR1, CNR2, CCKBR | CNR1 1/4885CNR2 2/4885ABHD12 3537/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.