Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | CLK1 | P49759 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11150743 | 1.00 | ALDH1A1 (0.48) | ALDH1A1TDP1KDM4EMAPTMAPK1 | |
| SCHEMBL11144882 | 0.93 | ALDH1A1 (0.45) | ALDH1A1TDP1KDM4EMAPTMAPK1 | |
| SCHEMBL11144761 | 0.92 | ALDH1A1 (0.44) | ALDH1A1TDP1KDM4EMAPTMAPK1 | |
| SCHEMBL11148554 | 0.85 | L3MBTL1 (0.46) | ALDH1A1TDP1MAPTMEN1KMT2A | |
| SCHEMBL11147165 | 0.84 | KMT2A (0.46) | ALDH1A1TDP1KDM4EMAPTMAPK1 | |
| SCHEMBL11147166 | 0.84 | KMT2A (0.46) | ALDH1A1TDP1KDM4EMAPTMAPK1 | |
| SCHEMBL11143146 | 0.82 | MEN1 (0.45) | ALDH1A1TDP1KDM4EMAPTMAPK1 | |
| SCHEMBL11155555 | 0.82 | GRM5 (0.46) | ALDH1A1MAPTMAPK1MEN1KMT2A | |
| SCHEMBL11149203 | 0.82 | KMT2A (0.45) | ALDH1A1TDP1MAPTMAPK1MEN1 | |
| SCHEMBL11143150 | 0.82 | MEN1 (0.45) | ALDH1A1TDP1KDM4EMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4402964-A | N-Aryl-N'-(3-methyl or ethyl-4-oxothiazolidinylidene)ureas useful for the treatment of epilepsy | MCNEILAB, INC. (US) | 1983-09-06 | — | — | US | claimed |