Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | DRD4 | P21917 | 2/20 | 0.40 |
| ▸ | CLK1 | P49759 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11150736 | 0.93 | ALDH1A1 (0.48) | ALDH1A1TDP1MAPTMAPK1KDM4E | |
| SCHEMBL11150743 | 0.93 | ALDH1A1 (0.48) | ALDH1A1TDP1MAPTMAPK1KDM4E | |
| SCHEMBL11147165 | 0.90 | KMT2A (0.46) | ALDH1A1TDP1MAPTMAPK1KDM4E | |
| SCHEMBL11147166 | 0.90 | KMT2A (0.46) | ALDH1A1TDP1MAPTMAPK1KDM4E | |
| SCHEMBL11144761 | 0.88 | ALDH1A1 (0.44) | ALDH1A1TDP1MAPTMAPK1KDM4E | |
| SCHEMBL11151136 | 0.86 | L3MBTL1 (0.42) | ALDH1A1MEN1KMT2ADRD4ATM | |
| SCHEMBL11141779 | 0.84 | GRM5 (0.42) | ALDH1A1MEN1KMT2ASMN1; SMN2PSMD14 | |
| SCHEMBL11144521 | 0.84 | GRM5 (0.42) | ALDH1A1MEN1KMT2ASMN1; SMN2PSMD14 | |
| SCHEMBL11146126 | 0.81 | RIPK1 (0.40) | ALDH1A1MAPTMAPK1MEN1KMT2A | |
| SCHEMBL10991240 | 0.81 | GRM5 (0.55) | ALDH1A1MEN1KMT2ADRD4ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4402964-A | N-Aryl-N'-(3-methyl or ethyl-4-oxothiazolidinylidene)ureas useful for the treatment of epilepsy | MCNEILAB, INC. (US) | 1983-09-06 | — | — | US | disclosed |