Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.43 |
| ▸ | ASAH1 | Q13510 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | APAF1 | O14727 | 1/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.40 |
| ▸ | FDPS | P14324 | 1/20 | 0.39 |
| ▸ | PLK1 | P53350 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2298534 | 0.72 | EGLN3 (0.45) | EGLN3ASAH1KDM4ENPC1SMN1; SMN2 | |
| SCHEMBL2794301 | 0.71 | HTT (0.48) | EGLN3ASAH1SMN1; SMN2HTTKMT2A | |
| SCHEMBL11578320 | 0.70 | NPC1 (0.43) | EGLN3ASAH1KDM4ENPC1SMN1; SMN2 | |
| SCHEMBL10683773 | 0.70 | APAF1 (0.44) | EGLN3ASAH1KDM4ENPC1SMN1; SMN2 | |
| Carbamic Acid SCHEMBL10888970 | 0.68 | SMN1; SMN2 (0.56) | EGLN3ASAH1KDM4ENPC1SMN1; SMN2 | |
| SCHEMBL828619 | 0.68 | KMT2A (0.57) | EGLN3ASAH1KDM4ENPC1SMN1; SMN2 | |
| SCHEMBL11882632 | 0.68 | KMT2A (0.57) | EGLN3ASAH1KDM4ENPC1SMN1; SMN2 | |
| SCHEMBL6175276 | 0.68 | FDPS (0.46) | EGLN3NPC1SMN1; SMN2APAF1FDPS | |
| SCHEMBL1038315 | 0.67 | KDM4E (0.69) | EGLN3KDM4ENPC1SMN1; SMN2APAF1 | |
| SCHEMBL15545884 | 0.67 | TDP1 (0.48) | SMN1; SMN2MKNK1MKNK2HTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4420479-A | 1-SUBSTITUTED, 2-AMINO-BENZIMIDAZOLES | ELI LILLY AND COMPANY (US) | 1983-12-13 | — | — | US | disclosed |
| EP-0091795-A1 | Olefinic benzimidazoles | ELI LILLY AND COMPANY (US) | 1983-10-19 | — | — | EP | disclosed |