Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | ASAH1 | Q13510 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | APAF1 | O14727 | 1/20 | 0.42 |
| ▸ | FDPS | P14324 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2295166 | 0.73 | FGFR1 (0.46) | CYP2C19HIF1ASMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL11152005 | 0.72 | EGLN3 (0.43) | EGLN3ASAH1SMN1; SMN2APAF1FDPS | |
| SCHEMBL10683773 | 0.72 | APAF1 (0.44) | EGLN3ASAH1SMN1; SMN2APAF1FDPS | |
| SCHEMBL2164037 | 0.71 | EGLN3 (0.45) | EGLN3CYP2C19ASAH1SMN1; SMN2APAF1 | |
| SCHEMBL3796582 | 0.70 | SMN1; SMN2 (0.44) | EGLN3ASAH1SMN1; SMN2APAF1FDPS | |
| SCHEMBL2794301 | 0.70 | HTT (0.48) | EGLN3ASAH1SMN1; SMN2HPGDLMNA | |
| SCHEMBL6175276 | 0.70 | FDPS (0.46) | EGLN3SMN1; SMN2APAF1FDPSHPGD | |
| SCHEMBL2614317 | 0.69 | NPC1 (0.49) | SMN1; SMN2FDPSKDM4EALDH1A1HPGD | |
| SCHEMBL14268957 | 0.69 | ALDH1A1 (0.47) | EGLN3CYP2C19ASAH1APAF1FDPS | |
| SCHEMBL6174967 | 0.68 | FDPS (0.46) | EGLN3ASAH1SMN1; SMN2APAF1FDPS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8003806-B2 | Integrin antagonists useful as anticancer agents | OSI Pharmaceuticals, LLC (US) | 2011-08-23 | — | — | US | disclosed |