Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MAOA | P21397 | 2/20 | 0.41 |
| ▸ | MAOB | P27338 | 2/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.41 |
| ▸ | HCAR1 | Q9BXC0 | 2/20 | 0.40 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.38 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.38 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.38 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1160085 | 0.74 | MAOA (0.43) | HSD17B10MEN1KMT2AMAOAMAOB | |
| SCHEMBL4187867 | 0.74 | HCAR1 (0.41) | HSD17B10MAOAMAOBCYP2A6HCAR1 | |
| SCHEMBL6114558 | 0.71 | CRBN (0.41) | HCAR1CA12CA1CA3CA4 | |
| SCHEMBL18250040 | 0.70 | MAOA (0.39) | HSD17B10MEN1KMT2AMAOAMAOB | |
| SCHEMBL3856824 | 0.70 | ALDH1A1 (0.44) | HSD17B10HCAR1GRIN2DGRIN3BGRIN1 | |
| Hydrochloric Acid SCHEMBL32680188 | 0.68 | ALDH1A1 (0.43) | HSD17B10HCAR1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL928810 | 0.68 | ALDH1A1 (0.43) | HSD17B10HCAR1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL9097365 | 0.67 | CA12 (0.31) | CA12CA1CA3CA4CA6 | |
| SCHEMBL4123765 | 0.67 | ALOX15 (0.45) | HSD17B10MEN1KMT2AMAOAMAOB | |
| SCHEMBL866759 | 0.67 | PKN1 (0.47) | HSD17B10MEN1KMT2AMAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0015543-B1 | 5,6,7,8-TETRAHYDRO-2,8-QUINOLINE DIONE AND PROCESS FOR ITS PREPARATION | HOECHST AKTIENGESELLSCHAFT (DE) | 1983-06-22 | — | — | EP | claimed |
| US-4277606-A | 8-Oxo-5,6,7,8-tetrahydro-2-quinolone and process for the preparation thereof | HOECHST AKTIENGESELLSCHAFT (DE) | 1981-07-07 | — | — | US | claimed |
| US-4277606-A | 8-Oxo-5,6,7,8-tetrahydro-2-quinolone and process for the preparation thereof | HOECHST AKTIENGESELLSCHAFT (DE) | 1981-07-07 | — | — | US | disclosed |
| US-4277606-A | 8-Oxo-5,6,7,8-tetrahydro-2-quinolone and process for the preparation thereof | HOECHST AKTIENGESELLSCHAFT (DE) | 1981-07-07 | — | — | US | disclosed |
| US-4277606-A | 8-Oxo-5,6,7,8-tetrahydro-2-quinolone and process for the preparation thereof | HOECHST AKTIENGESELLSCHAFT (DE) | 1981-07-07 | — | — | US | disclosed |