Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | VDR | P11473 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.34 |
| ▸ | RELA | Q04206 | 3/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.33 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1115657 | 1.00 | USP2 (0.38) | USP2VDRCYP1A2CYP2C19MEN1 | |
| SCHEMBL1115366 | 1.00 | USP2 (0.38) | USP2VDRCYP1A2CYP2C19MEN1 | |
| SCHEMBL1115711 | 0.85 | GPBAR1 (0.39) | MAPT | |
| SCHEMBL1115527 | 0.76 | NPC1L1 (0.43) | USP2ALDH1A1MAPTCYP19A1LMNA | |
| SCHEMBL1115367 | 0.75 | CYP2C19 (0.36) | USP2VDRCYP2C19MEN1KMT2A | |
| SCHEMBL7296751 | 0.75 | CYP2C19 (0.40) | CYP2C19MEN1KMT2AMAPK1TP53 | |
| SCHEMBL1115659 | 0.75 | CYP2C19 (0.36) | USP2VDRCYP2C19MEN1KMT2A | |
| SCHEMBL7298622 | 0.72 | CYP2C19 (0.45) | CYP1A2CYP2C19MEN1KMT2AMAPK1 | |
| SCHEMBL7295857 | 0.72 | CYP2C19 (0.45) | CYP1A2CYP2C19MEN1KMT2AMAPK1 | |
| SCHEMBL11241545 | 0.71 | USP2 (0.57) | USP2VDRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8022203-B2 | Amino derivatives of beta-homoandrostanes and beta-heteroandrostanes | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2011-09-20 | — | — | US | disclosed |
| EP-2032593-B1 | AMINO DERIVATIVES OF B-HOMOANDROSTANES AND B-HETEROANDROSTANES | SIGMA TAU IND FARMACEUTI (IT) | 2011-02-02 | — | — | EP | disclosed |
| US-20090209506-A1 | AMINO DERIVATIVES OF BETA-HOMOANDROSTANES AND BETA-HETEROANDROSTANES | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2009-08-20 | — | — | US | disclosed |
| EP-2032593-A1 | AMINO DERIVATIVES OF B-HOMOANDROSTANES AND B-HETEROANDROSTANES | SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. (IT) | 2009-03-11 | — | — | EP | disclosed |
| WO-2007147713-A1 | AMINO DERIVATIVES OF B-HOMOANDROSTANES AND B-HETEROANDROSTANES | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2007-12-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090209506-A1 | AMINO DERIVATIVES OF BETA-HOMOANDROSTANES AND BETA-HETEROANDROSTANES | CYP11B2, PTGIS, PTGER1 | USP2 3239/4885VDR 276/4885CYP1A2 66/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.