Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PPM1D | O15297 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | VDR | P11473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1115367 | 1.00 | CYP2C19 (0.36) | CYP2C19MAPK1ALDH1A1TP53MAPT | |
| SCHEMBL7296751 | 0.96 | CYP2C19 (0.40) | CYP2C19MAPK1TP53MAPTCYP19A1 | |
| SCHEMBL1115738 | 0.84 | GPBAR1 (0.35) | MAPTPPM1D | |
| SCHEMBL1115709 | 0.84 | GPBAR1 (0.35) | MAPTPPM1D | |
| SCHEMBL1060416 | 0.81 | GRIN2D (0.45) | CYP2C19MAPK1MEN1KMT2ALMNA | |
| SCHEMBL18716764 | 0.81 | GRIN2D (0.45) | CYP2C19MAPK1MEN1KMT2ALMNA | |
| SCHEMBL7296749 | 0.81 | CYP19A1 (0.38) | CYP2C19MAPK1TP53MAPTPPM1D | |
| SCHEMBL8964923 | 0.76 | GABRP (0.39) | MAPK1TP53MAPTCYP19A1MEN1 | |
| SCHEMBL1115368 | 0.75 | USP2 (0.38) | CYP2C19MAPK1ALDH1A1TP53MAPT | |
| SCHEMBL1115366 | 0.75 | USP2 (0.38) | CYP2C19MAPK1ALDH1A1TP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8022203-B2 | Amino derivatives of beta-homoandrostanes and beta-heteroandrostanes | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2011-09-20 | — | — | US | disclosed |
| EP-2032593-B1 | AMINO DERIVATIVES OF B-HOMOANDROSTANES AND B-HETEROANDROSTANES | SIGMA TAU IND FARMACEUTI (IT) | 2011-02-02 | — | — | EP | disclosed |
| US-20090209506-A1 | AMINO DERIVATIVES OF BETA-HOMOANDROSTANES AND BETA-HETEROANDROSTANES | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2009-08-20 | — | — | US | disclosed |
| EP-2032593-A1 | AMINO DERIVATIVES OF B-HOMOANDROSTANES AND B-HETEROANDROSTANES | SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. (IT) | 2009-03-11 | — | — | EP | disclosed |
| WO-2007147713-A1 | AMINO DERIVATIVES OF B-HOMOANDROSTANES AND B-HETEROANDROSTANES | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2007-12-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090209506-A1 | AMINO DERIVATIVES OF BETA-HOMOANDROSTANES AND BETA-HETEROANDROSTANES | CYP11B2, PTGIS, PTGER1 | CYP2C19 101/4885MAPK1 2112/4885ALDH1A1 734/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.