Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 9/20 | 0.46 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.45 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.45 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.43 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.43 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.43 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11160325 | 0.85 | GRM2 (0.62) | GRM2HTR2BMAPK1L3MBTL1 | |
| SCHEMBL24933695 | 0.81 | GRM2 (0.51) | GRM2HTR2BMAPK1L3MBTL1 | |
| SCHEMBL3372293 | 0.81 | GRM2 (0.63) | GRM2HTR2BMAPK1L3MBTL1 | |
| SCHEMBL11161832 | 0.79 | GRM2 (0.50) | GRM2HTR2BMAPK1L3MBTL1 | |
| SCHEMBL7909523 | 0.79 | GRM2 (0.49) | GRM2HTR2BMAPK1L3MBTL1 | |
| SCHEMBL11153784 | 0.78 | GRM2 (0.43) | GRM2HTR2BMAPK1L3MBTL1 | |
| SCHEMBL9636573 | 0.76 | GRM2 (0.47) | GRM2HTR2BMAPK1L3MBTL1 | |
| SCHEMBL9636582 | 0.76 | GRM2 (0.47) | GRM2HTR2BMAPK1L3MBTL1 | |
| SCHEMBL11875374 | 0.75 | HTR2B (0.47) | GRM2CHRNB4CHRNA3HTR2BMAPK1 | |
| SCHEMBL11154054 | 0.73 | ADRB2 (0.45) | GRM2HTR2BMAPK1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4410530-A | CARDIO-SELECTIVE B-RECEPTOR BLOCKING AGENTS AND STIMULANTS | CIBA-GEIGY CORPORATION (US) | 1983-10-18 | — | — | US | disclosed |
| US-4195090-A | ADRENERGIC BLOCKING AGENTS | CIBA-GEIGY CORPORATION (US) | 1980-03-25 | — | — | US | disclosed |
| US-4115575-A | CARDIOVASCULAR DISORDERS | CIBA-GEIGY CORPORATION (US) | 1978-09-19 | — | — | US | disclosed |