Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 11/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | NPY1R | P25929 | 1/20 | 0.39 |
| ▸ | NPY2R | P49146 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9636582 | 1.00 | GRM2 (0.47) | GRM2MAPK1L3MBTL1NR3C1ADRB2 | |
| SCHEMBL11161832 | 0.84 | GRM2 (0.50) | GRM2MAPK1L3MBTL1HTR2B | |
| SCHEMBL11160325 | 0.83 | GRM2 (0.62) | GRM2MAPK1L3MBTL1HTR2BNPSR1 | |
| SCHEMBL24933695 | 0.82 | GRM2 (0.51) | GRM2MAPK1L3MBTL1CYP2D6HTR2B | |
| SCHEMBL3372293 | 0.81 | GRM2 (0.63) | GRM2MAPK1L3MBTL1HTR2BTDP1 | |
| SCHEMBL11154054 | 0.80 | ADRB2 (0.45) | GRM2MAPK1L3MBTL1ADRB2ADRB1 | |
| SCHEMBL7909523 | 0.80 | GRM2 (0.49) | GRM2MAPK1L3MBTL1HTR2B | |
| SCHEMBL11154145 | 0.76 | GRM2 (0.46) | GRM2MAPK1L3MBTL1HTR2B | |
| SCHEMBL4902039 | 0.75 | ALDH1A1 (0.57) | NR3C1ADRB2ADRB1CYP2D6ADRA1A | |
| SCHEMBL4081261 | 0.75 | ALDH1A1 (0.57) | NR3C1ADRB2ADRB1CYP2D6ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013141437-A1 | METHOD FOR MANUFACTURING HIGH PURITY (S)-METOPROLOL | 주식회사 알에스텍 (KR) | 2013-09-26 | — | — | WO | disclosed |
| EP-0339006-B1 | PROCESS FOR PREPARING S-METOPROLOL AND INTERMEDIATES THEREFOR | Astra Pharmaceutical Production AB (SE) | 1992-07-08 | — | — | EP | disclosed |
| US-5034535-A | Multistage reaction with chloroformate ester and isopropylamino-1,2-propanediol for cyclization, sulfonation and etherification | ASTRA PHARMACEUTICAL PRODUCTION AKTIEBOLAG (SE) | 1991-07-23 | — | — | US | disclosed |
| EP-0339006-A1 | Process for preparing S-metoprolol and intermediates therefor | Astra Pharmaceutical Production AB (SE) | 1989-10-25 | — | — | EP | disclosed |