Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRPF1 | P55201 | 5/20 | 0.38 |
| ▸ | KIF11 | P52732 | 1/20 | 0.37 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.32 |
| ▸ | MTTP | P55157 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | BRD1 | O95696 | 1/20 | 0.31 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.31 |
| ▸ | BRPF3 | Q9ULD4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18537527 | 0.76 | KIF11 (0.53) | KIF11GAAMAPTMTTPKMT2A | |
| SCHEMBL8899522 | 0.76 | RXFP1 (0.43) | MAPTRXFP1MEN1KMT2AKDM4E | |
| SCHEMBL31435622 | 0.76 | MCL1 (0.50) | SMN1; SMN2MAPTMEN1MAPK1KMT2A | |
| SCHEMBL12900640 | 0.73 | KDM4E (0.31) | MAPTRXFP1ALDH1A1KDM4EHPGD | |
| SCHEMBL8898917 | 0.73 | KMT2A (0.48) | BRPF1KIF11MAPTMEN1KMT2A | |
| SCHEMBL1113031 | 0.72 | XDH (0.41) | BRPF1KIF11BRD4BRD1BRD9 | |
| SCHEMBL27684724 | 0.71 | THRB (0.50) | SMN1; SMN2GAATHRBMAPTRXFP1 | |
| SCHEMBL12320558 | 0.68 | KIF11 (0.36) | KIF11 | |
| SCHEMBL12320518 | 0.68 | KIF11 (0.36) | KIF11 | |
| SCHEMBL12320842 | 0.67 | KIF11 (0.44) | KIF11MAPTNPY5RMEN1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2279184-A1 | INDOLE MODULATORS OF THE ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR | Glaxo Group Limited (GB) | 2011-02-02 | — | — | EP | disclosed |