Maleic Acid

SCHEMBL11157243

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nearest known ligand 0.73

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACE ADRA1A ADRA1B ADRA1D ADRA2A ADRA2B ADRA2C ADRB1 ADRB2 BTK CACNA1C CACNA1D CACNA1F CACNA1S CCR5 CPT1B CPT2 DPP4 DRD1 DRD2 EGFR ERBB2 ERBB4 HRH1 HRH3 HTR1A HTR2A HTR2B HTR2C HTR4 JAK1 JAK2 JAK3 MPL MTOR P PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R5 PPARG SLC6A2 SLC6A3 SLC6A4 SMO TYK2 pol

The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

	gene	UniProt	supporting neighbours	confidence
▸	TSHR	P16473	4/20	0.60

▸	TP53	P04637	1/20	0.60

▸	EGLN1	Q9GZT9	1/20	0.60

▸	EGLN3	Q9H6Z9	1/20	0.60

▸	HCAR2	Q8TDS4	3/20	0.39

▸	CA1	P00915	2/20	0.36

▸	CA9	Q16790	1/20	0.36

▸	CA4	P22748	1/20	0.35

▸	FAHD1	Q6P587	1/20	0.35

▸	GABRR1	P24046	2/20	0.35

▸	GABRR2	P28476	2/20	0.35

▸	BLM	P54132	2/20	0.35

▸	TDP1	Q9NUW8	2/20	0.35

▸	GABRR3	A8MPY1	1/20	0.35

▸	LMNA	P02545	1/20	0.35

▸	APEX1	P27695	1/20	0.35

▸	NPSR1	Q6W5P4	1/20	0.35

▸	ALDH1A1	P00352	2/20	0.35

▸	GAA	P10253	1/20	0.35

▸	ALOX15	P16050	1/20	0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Fumaric Acid SCHEMBL28608401	1.00	TSHR (0.60)	TSHRTP53EGLN1EGLN3HCAR2
Fumaric Acid SCHEMBL30578900	1.00	TSHR (0.60)	TSHRTP53EGLN1EGLN3HCAR2
Fumaric Acid SCHEMBL106606	1.00	—	—
Maleic Acid SCHEMBL8163405	1.00	TSHR (0.60)	TSHRTP53EGLN1EGLN3HCAR2
Fumaric Acid SCHEMBL107031	1.00	—	—
Fumaric Acid SCHEMBL263297	1.00	TSHR (0.60)	TSHRTP53EGLN1EGLN3HCAR2
Maleic Acid SCHEMBL7961962	1.00	TSHR (0.60)	TSHRTP53EGLN1EGLN3HCAR2
Fumaric Acid SCHEMBL263298	1.00	TSHR (0.60)	TSHRTP53EGLN1EGLN3HCAR2
Fumaric Acid SCHEMBL5799074	1.00	TSHR (0.60)	TSHRTP53EGLN1EGLN3HCAR2
Fumaric Acid SCHEMBL106604	1.00	—	—

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-4416809-A	SULFO FATTY ACID ESTER SALT, FATTY ACID SOAP, AND POLYCARBOXYLIC ACID SALT	LION CORPORATION (JP)	1983-11-22	—	—	US	disclosed