Fumaric Acid

Fumaric Acid

SCHEMBL107031

O=C([O-])/C=C\C(=O)O.[Na+]

nearest known ligand 0.00

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Known targets — ChEMBL curated mechanism

ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol

The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Fumaric Acid SCHEMBL28608401 1.00 TSHR (0.60)
Maleic Acid SCHEMBL11157243 1.00 TSHR (0.60)
Fumaric Acid SCHEMBL30578900 1.00 TSHR (0.60)
Fumaric Acid SCHEMBL106606 1.00
Maleic Acid SCHEMBL8163405 1.00 TSHR (0.60)
Fumaric Acid SCHEMBL263297 1.00 TSHR (0.60)
Maleic Acid SCHEMBL7961962 1.00 TSHR (0.60)
Fumaric Acid SCHEMBL263298 1.00 TSHR (0.60)
Fumaric Acid SCHEMBL5799074 1.00 TSHR (0.60)
Fumaric Acid SCHEMBL106604 1.00

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1050 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4616027-A1 IMPROVED SCALE INHIBITION FOR PULP DIGESTERS Ecolab USA Inc. (US) 2025-09-17 EP claimed
US-20240315956-A1 METHOD OF PRODUCTION OF THE COMPOSITION OF CYCLOOXYGENASE-2 (COX-2) INHIBITORS US Nano Food & Drug INC 2024-09-26 US claimed
WO-2024155511-A1 IMPROVED SCALE INHIBITION FOR PULP DIGESTERS ECOLAB USA INC. (US) 2024-07-25 WO claimed
US-20240247439-A1 SCALE INHIBITION FOR PULP DIGESTERS ECOLAB USA INC. (US) 2024-07-25 US claimed
EP-4366732-A1 METHOD OF PRODUCTION OF THE COMPOSITION OF CYCLOOXYGENASE-2 (COX-2) INHIBITORS US Nano Food & Drug Inc (US) 2024-05-15 EP claimed
CN-117813089-A Process for producing cyclooxygenase-2 (COX-2) inhibitor composition 美国纳米食品药品公司 2024-04-02 CN claimed
CN-117239128-A Multifunctional positive electrode slurry additive based on Lewis acid-base self-assembly and application of multifunctional positive electrode slurry additive in sodium ion battery 北京理工大学 2023-12-15 CN claimed
US-11813364-B2 Patch HISAMITSU PHARMACEUTICAL CO., INC. (JP) 2023-11-14 US claimed
WO-2023281449-A1 METHOD OF PRODUCTION OF THE COMPOSITION OF CYCLOOXYGENASE-2 (COX-2) INHIBITORS US Nano Food & Drug INC (US) 2023-01-12 WO claimed
US-20210369638-A1 PATCH HISAMITSU PHARMACEUTICAL CO., INC. (JP) 2021-12-02 US claimed
EP-0372866-A1 Use of a Nylon/grafted polyolefine release film for sheet moulding compound Du Pont Canada Inc. (CA) 1990-06-13 EP claimed
EP-0372869-A1 Nylon/grafted terpolymer release film for sheet moulding compound Du Pont Canada Inc. (CA) 1990-06-13 EP claimed
EP-0364697-A1 Process for preparing ether-carboxylic acids and salts MONSANTO COMPANY (US) 1990-04-25 EP claimed
CN-1041175-A Improved co-extrusion tackiness agent and goods thereof DU PONT (US) 1990-04-11 CN claimed
EP-0355809-A1 Process for preparing ether-carboxylic acids and salts MONSANTO COMPANY (US) 1990-02-28 EP claimed
EP-0355807-A2 Process for the manufacture of ether carboxylic acids MONSANTO COMPANY (US) 1990-02-28 EP claimed
US-4668735-A MONOSODIUM, MONOPOTASSIUM, MONOAMMONIUM MALEATE; SOLUTION POLYMERIZATION KAO CORPORATION (JP) 1987-05-26 US claimed
US-4162194-A DEETHERIFICATION, PHOSPHORYLATION AND TRANSPHOSPHORYLATION BECKMAN INSTRUMENTS, INC. (US) 1979-07-24 US claimed
US-4061465-A Creasable durable press textiles from methylol reagents and half amides or half salts of dicarboxylic acids THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF AGRICULTURE (US) 1977-12-06 US claimed
US-4053612-A FUNGICIDES E. I. DU PONT DE NEMOURS AND COMPANY (US) 1977-10-11 US claimed