Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK1 | P49759 | 2/20 | 0.41 |
| ▸ | CLK2 | P49760 | 2/20 | 0.41 |
| ▸ | DYRK2 | Q92630 | 2/20 | 0.41 |
| ▸ | GSK3A | P49840 | 2/20 | 0.41 |
| ▸ | GSK3B | P49841 | 2/20 | 0.41 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.41 |
| ▸ | DYRK4 | Q9NR20 | 1/20 | 0.41 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.34 |
| ▸ | MAPT | P10636 | 6/20 | 0.34 |
| ▸ | POLB | P06746 | 6/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 8/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.33 |
| ▸ | MEN1 | O00255 | 5/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1115917 | 1.00 | CLK1 (0.41) | CLK1CLK2DYRK2GSK3AGSK3B | |
| SCHEMBL1116166 | 0.78 | CA2 (0.38) | CLK1CLK2DYRK2GSK3AGSK3B | |
| SCHEMBL1116165 | 0.78 | CA2 (0.38) | CLK1CLK2DYRK2GSK3AGSK3B | |
| SCHEMBL1115931 | 0.78 | MAPT (0.51) | CLK1CLK2DYRK2GSK3AGSK3B | |
| SCHEMBL1115930 | 0.78 | MAPT (0.51) | CLK1CLK2DYRK2GSK3AGSK3B | |
| SCHEMBL6859308 | 0.74 | IDH1 (0.41) | GSK3AGSK3BALDH1A1MAPTPOLB | |
| SCHEMBL1116271 | 0.72 | BRD4 (0.53) | ALDH1A1MAPTPOLBLMNARAB9A | |
| SCHEMBL1116258 | 0.70 | CLK1 (0.38) | CLK1CLK2DYRK2GSK3AGSK3B | |
| SCHEMBL1116038 | 0.70 | MAPT (0.41) | CLK1CLK2DYRK2GSK3AGSK3B | |
| SCHEMBL1116039 | 0.70 | MAPT (0.41) | CLK1CLK2DYRK2GSK3AGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011015646-A2 | FURAN-IMIDAZOLONE DERIVATIVES, FOR THE TREATMENT OF COGNITIVE, NEURODEGENERATIVE OR NEURONAL DISEASES OR DISORDERS | NOSCIRA, S.A. (ES) | 2011-02-10 | — | — | WO | disclosed |
| EP-2281824-A1 | Furan-imidazolone derivatives, for the treatment of cognitive, neurodegenerative or neuronal diseases or disorders | NOSCIRA, S.A. (ES) | 2011-02-09 | — | — | EP | disclosed |