Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 1/20 | 0.41 |
| ▸ | GSK3A | P49840 | 2/20 | 0.41 |
| ▸ | GSK3B | P49841 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 11/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.37 |
| ▸ | PKM | P14618 | 7/20 | 0.37 |
| ▸ | MEN1 | O00255 | 6/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 4/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.36 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.36 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.36 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1115917 | 0.74 | CLK1 (0.41) | GSK3AGSK3BMAPTALDH1A1KDM4E | |
| SCHEMBL1115919 | 0.74 | CLK1 (0.41) | GSK3AGSK3BMAPTALDH1A1KDM4E | |
| SCHEMBL1116271 | 0.71 | BRD4 (0.53) | MAPTALDH1A1KDM4EKMT2APKM | |
| SCHEMBL1116166 | 0.70 | CA2 (0.38) | GSK3AGSK3BMAPTALDH1A1KDM4E | |
| SCHEMBL1116165 | 0.70 | CA2 (0.38) | GSK3AGSK3BMAPTALDH1A1KDM4E | |
| SCHEMBL13056356 | 0.58 | GSK3A (0.78) | IDH1GSK3AGSK3BMAPTALDH1A1 | |
| SCHEMBL28747775 | 0.58 | AR (0.49) | MAPTALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL14005636 | 0.57 | AHR (0.73) | IDH1MAPTALDH1A1KDM4EKMT2A | |
| SCHEMBL2899566 | 0.56 | MAPT (0.51) | IDH1GSK3AGSK3BMAPTALDH1A1 | |
| SCHEMBL15980859 | 0.55 | BRD4 (0.58) | BRD4BRD2CREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011015646-A2 | FURAN-IMIDAZOLONE DERIVATIVES, FOR THE TREATMENT OF COGNITIVE, NEURODEGENERATIVE OR NEURONAL DISEASES OR DISORDERS | NOSCIRA, S.A. (ES) | 2011-02-10 | — | — | WO | disclosed |
| EP-2281824-A1 | Furan-imidazolone derivatives, for the treatment of cognitive, neurodegenerative or neuronal diseases or disorders | NOSCIRA, S.A. (ES) | 2011-02-09 | — | — | EP | disclosed |