Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.38 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.38 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.38 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.38 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 4/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CLK1 | P49759 | 1/20 | 0.37 |
| ▸ | CLK2 | P49760 | 1/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 6/20 | 0.34 |
| ▸ | GSK3A | P49840 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.33 |
| ▸ | NEK6 | Q9HC98 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1116165 | 1.00 | CA2 (0.38) | CA2DYRK3PIM1CSNK2A2CSNK2B | |
| SCHEMBL1115917 | 0.78 | CLK1 (0.41) | DYRK3DYRK1ADYRK2DYRK1BCLK1 | |
| SCHEMBL1115919 | 0.78 | CLK1 (0.41) | DYRK3DYRK1ADYRK2DYRK1BCLK1 | |
| SCHEMBL1116168 | 0.74 | CA2 (0.42) | CA2DYRK3PIM1CSNK2A2CSNK2B | |
| SCHEMBL1116262 | 0.73 | HTR2A (0.54) | CA2HTR2ACA1CLK1CLK2 | |
| SCHEMBL1116264 | 0.73 | HTR2A (0.54) | CA2HTR2ACA1CLK1CLK2 | |
| SCHEMBL1116271 | 0.72 | BRD4 (0.53) | BRD4BRD2KDM4EALDH1A1POLB | |
| SCHEMBL12899354 | 0.71 | HTR2A (0.50) | CA2DYRK3PIM1CSNK2A2CSNK2B | |
| SCHEMBL6859308 | 0.70 | IDH1 (0.41) | BRD4GSK3AGSK3BBRD2KDM4E | |
| SCHEMBL1228305 | 0.70 | BRAF (0.60) | GSK3AGSK3BDUSP3ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011015646-A2 | FURAN-IMIDAZOLONE DERIVATIVES, FOR THE TREATMENT OF COGNITIVE, NEURODEGENERATIVE OR NEURONAL DISEASES OR DISORDERS | NOSCIRA, S.A. (ES) | 2011-02-10 | — | — | WO | disclosed |
| EP-2281824-A1 | Furan-imidazolone derivatives, for the treatment of cognitive, neurodegenerative or neuronal diseases or disorders | NOSCIRA, S.A. (ES) | 2011-02-09 | — | — | EP | disclosed |