Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 5/20 | 0.53 |
| ▸ | ERN1 | O75460 | 5/20 | 0.46 |
| ▸ | BRD2 | P25440 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3101765 | 0.73 | ERN1 (0.56) | BRD4ERN1BRD2ALDH1A1MEN1 | |
| SCHEMBL1116165 | 0.72 | CA2 (0.38) | BRD4BRD2KDM4EALDH1A1MAPT | |
| SCHEMBL1116166 | 0.72 | CA2 (0.38) | BRD4BRD2KDM4EALDH1A1MAPT | |
| SCHEMBL3039493 | 0.72 | ALDH1A1 (0.50) | KDM4EALDH1A1LMNAGAACYP2E1 | |
| SCHEMBL1115919 | 0.72 | CLK1 (0.41) | BRD4BRD2KDM4EALDH1A1LMNA | |
| SCHEMBL1115917 | 0.72 | CLK1 (0.41) | BRD4BRD2KDM4EALDH1A1LMNA | |
| SCHEMBL28747775 | 0.71 | AR (0.49) | BRD4ERN1BRD2KDM4EALDH1A1 | |
| SCHEMBL6656195 | 0.71 | ALDH1A1 (0.61) | KDM4EALDH1A1LMNAGAACYP2E1 | |
| SCHEMBL6859308 | 0.71 | IDH1 (0.41) | BRD4BRD2KDM4EALDH1A1LMNA | |
| SCHEMBL2323855 | 0.70 | ALDH1A1 (0.44) | KDM4EALDH1A1LMNAGAACYP2E1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011015646-A2 | FURAN-IMIDAZOLONE DERIVATIVES, FOR THE TREATMENT OF COGNITIVE, NEURODEGENERATIVE OR NEURONAL DISEASES OR DISORDERS | NOSCIRA, S.A. (ES) | 2011-02-10 | — | — | WO | disclosed |
| WO-2011015646-A2 | FURAN-IMIDAZOLONE DERIVATIVES, FOR THE TREATMENT OF COGNITIVE, NEURODEGENERATIVE OR NEURONAL DISEASES OR DISORDERS | NOSCIRA, S.A. (ES) | 2011-02-10 | — | — | WO | disclosed |
| EP-2281824-A1 | Furan-imidazolone derivatives, for the treatment of cognitive, neurodegenerative or neuronal diseases or disorders | NOSCIRA, S.A. (ES) | 2011-02-09 | — | — | EP | disclosed |
| EP-2281824-A1 | Furan-imidazolone derivatives, for the treatment of cognitive, neurodegenerative or neuronal diseases or disorders | NOSCIRA, S.A. (ES) | 2011-02-09 | — | — | EP | disclosed |