Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2C | P18825 | 1/20 | 0.47 |
| ▸ | CACNA1B | Q00975 | 5/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.44 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.44 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | IL18 | Q14116 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11164984 | 0.83 | MAPT (0.46) | ADRA2CMEN1MAPTKMT2APKM | |
| SCHEMBL7815135 | 0.83 | ADRA2C (0.59) | ADRA2CMEN1MAPTKMT2APKM | |
| SCHEMBL11160995 | 0.82 | CACNA1H (0.49) | ADRA2CCACNA1BPARP10MEN1MAPT | |
| SCHEMBL11158176 | 0.81 | NPSR1 (0.57) | ADRA2CSLC6A4MEN1MAPTKMT2A | |
| SCHEMBL11163188 | 0.81 | L3MBTL1 (0.53) | ADRA2CSLC6A4MEN1MAPTKMT2A | |
| SCHEMBL11164283 | 0.81 | ADRA2C (0.47) | ADRA2CSLC6A4MEN1MAPTKMT2A | |
| SCHEMBL11160894 | 0.80 | EPHX1 (0.55) | ADRA2CMEN1MAPTKMT2AKDM4E | |
| SCHEMBL11165605 | 0.77 | ALDH1A1 (0.51) | ADRA2CCACNA1BMEN1MAPTKMT2A | |
| SCHEMBL28558177 | 0.76 | ALDH1A1 (0.53) | PARP15PARP10PARP2MEN1MAPT | |
| Iodide SCHEMBL11157435 | 0.76 | CACNA1B (0.45) | ADRA2CCACNA1BSLC6A4MEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0017484-B1 | 2-IMIDAZOLINE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND THE PHARMACEUTICAL COMPOSITION OF THE SAME | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1983-04-06 | — | — | EP | disclosed |
| EP-0017484-A1 | 2-Imidazoline derivatives, process for the preparation thereof and the pharmaceutical composition of the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1980-10-15 | — | — | EP | disclosed |